The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
Exocytosis of intracellular granules is critical for conversion of inactive, circulating neutrophils to fully activated cells. The p38 MAPK pathway plays a central role in neutrophil exocytosis, although its mechanism of action is unknown. We used...
Nanoparticles; Imaging systems in medicine; Imaging systems in biology
Gold nanoparticles (GNPs) have shown beneficial properties for biomedical use, e.g., their non-toxic nature and surface properties for easy modification. Upon receiving light, they generate a strong surface plasmon field, which can alter the...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are highly reactive á,â-unsaturated aldehydes. 4-HNE and acrolein are generated in vivo as products of lipid peroxidation. These aldehydes are implicated in the onset of several diseases...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
Outerplanar graphs are planar graphs that have a plane embedding in which each vertex lies on the boundary of the exterior region. An outerplanar graph is maximal outerplanar if the graph obtained by adding an edge is not outerplanar. Maximal...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
City planning--Psychological aspects; City planning--Citizen participation
This dissertation examines the impact of complexity and familiarity on visual preference for two content domains defined as Neo-Traditional and Modern. This research has five main themes: (1) To determine if there is a method for community design...
Children with visual disabilities--Services for--Kentucky; Children with visual disabilities--Education--Kentucky; Self-help devices for people with disabilities--Kentucky; Students with disabilities--Services for--Kentucky
Assistive technology (AT) helps make the curriculum accessible to students with visual impairments. Studies have shown that half of these students are using assistive technologies. The purpose of this study was to seek a better understanding of the...
Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...
The field of graph theory has been indubitably influenced by the study of planar graphs. This thesis, consisting of five chapters, is a historical account of the origins and development of concepts pertaining to planar graphs and their...
Clement VI, Pope, ca 1291-1352; Popes--Primacy--History; Popes--Temporal power--History
The papacy of Clement VI (1342-1352) was distinguished by
its political activism, its attempt to resurrect the impetus
for crusading, and its efforts to attract the best and
brightest talents to Avignon. The attributes which
characterize his...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Art museums--Collection management; Rowling, Charles, 1935-2008; Kentucky Museum of Art and Craft
This Curatorial project examines issues that museums face in the documentation of permanent collections, using the Kentucky Museum of Art and Craft (KMAC) and its piece Angel, by Charles Rolwing, as specific examples. The project focuses on museum...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
