Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
Circulating nucleated cell populations found in whole blood, including both white blood cells (leukocytes) and endothelial cells, provide an ideal platform for studies seeking to understand the disease processes for development of drugs and...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
Exocytosis of intracellular granules is critical for conversion of inactive, circulating neutrophils to fully activated cells. The p38 MAPK pathway plays a central role in neutrophil exocytosis, although its mechanism of action is unknown. We used...
Exterior view of Model Drug Store, Schuster building on corner of Bardstown Road and Eastern Parkway, Louisville, Kentucky; signs advertise Luncheonette, Soda Fountain, Circulating Library, and Free Delivery. Bicycles lean against curb of lawn next...
Buildings; University of Louisville--Buildings; Libraries; Abstract sculpture;
Kornhauser Health Sciences Library and Commons building stands on the lefthand side of this image, behind the sculpture, Ad Astra. The Research Tower rises in the center of the image, and the Instructional Building can be seen on the right. The...
Buildings; University of Louisville--Buildings; Libraries; Ad Astra (Sculpture); Abstract sculpture; Public sculpture; Courtyards;
Kornhauser Health Sciences Library and Commons building with Ad Astra and the surrounding courtyard in the foreground. The Research Tower rises in the corner of the image. The Kornhauser Library has existed in various forms since its founding in...
Buildings; University of Louisville--Buildings; Libraries; Ad Astra (Sculpture); Abstract sculpture; Public sculpture; Fountains; Courtyards;
Kornhauser Health Sciences Library and Commons building with the fountain in the foreground and Ad Astra in the left corner. The Kornhauser Library has existed in various forms since its founding in 1837 as the library of the Louisville Medical...
Buildings; University of Louisville--Buildings; Libraries;
Kornhauser Health Sciences Library and Commons building seen from the walkway across Preston Street. The Research Tower rises in the background. The Kornhauser Library has existed in various forms since its founding in 1837 as the library of the...
