Older people--Mental health; Rural health; Urban health
Depression is one of the most prevalent psychiatric conditions experienced by older adults and represents a major public health concern. Rural/urban residence may affect the prevalence of depression as rural older adults differ from their urban...
Medical care, Cost of--Research--United States; Poor-- Medical care--United States
This thesis uses data from the 2002 Medical Expenditure Panel Survey in a quantitative examination of the capacity of the labor market in the United States to provide employment to the poor which enables them to afford health care. The...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
Background. Progression of alcoholic liver disease (ALD) is associated with an increase in fibrin extracellular matrix (ECM) and inflammation. Previous studies have shown that this accumulation of fibrin in ALD is mediated by impaired fibrinolysis....
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
It has been estimated that 30% of all cancer deaths in the U.S. are associated with obesity. It is well-established that obesity promotes low-grade chronic inflammation, however the mechanisms by which obesity-induced chronic inflammation may...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Obesity in children; Obesity in adolescence; Orthodontics
The purpose of this study was to determine if obesity impacts craniofacial dimensions in adolescent and teenage subjects. Twenty-one cephalometric measurements were selected as a basis for comparison between normal weight, overweight and obese...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
Wit and humor--Therapeutic use; Behavior therapy; Wit and humor--Psychological aspects
Objective: To evaluate the influence of positive affect inductions on daily and weekly Positive and Negative Affect Scales (PANAS) in a community setting. Methods: Humor messages were distributed to participants four times per day during a...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
Electromyography; Spinal cord--Wounds and injuries
Introduction: Approximately 12,000 new cases of spinal cord injury (SCI) are reported each year in the US. Currently, the most widely used method of assessing the recovery of voluntary capability after spinal cord injury is the American Spinal...
Aim. The efficacy of ridge preservation procedures using grafting materials and barrier membranes has been well established in the literature. However, the loss of horizontal width even with the utilization of intrasocket only guided bone...
Swarm Intelligence (SI) techniques were inspired by bee swarms, ant colonies, and most
recently, bird flocks. Flock-based Swarm Intelligence (FSI) has several unique features, namely
decentralized control, collaborative learning, high exploration...
