Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Capital punishment--Public opinion; Murder victims' families--Attitudes; Murder victims' families--Psychology
Two common assumptions are that the family members of murder victims will achieve closure and perceive a sense of justice following the execution of their loved one's murderer. These assumptions, however, may be unfounded. Using family member...
This study compared brief, single sessions of physical activity (PA, self-paced treadmill walking) and relaxation/meditation (R/M, the "Body Scan") on positive and negative affect and anxiety measures in female undergraduates. Both were...
Background - Cranial cruciate ligament (CrCL) rupture in the canine stifle is a leading
cause of orthopedic lameness in the dog. Several corrective surgical procedures have
been developed to return dogs to pre-injury function following CrCL...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
Activity-based rehabilitation is important for clinically treating spinal cord injury (SCI). Advances in SCI research are dependent on quality animal models, which rely on our ability to detect functional differences in animals following injury....
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
Aim. To compare two techniques of ridge preservation using a mineralized cancellous particulate allograft to a mineralized cortical particulate allograft plus an acelluar dermal matrix barrier membrane using clinical and histologic data to assess...
Louisville (Ky.)--History; Louisville (Ky.)--Social conditions; Cities and towns--Kentucky--History; Louisville (Ky.)--Economic conditions; Cities and towns--Growth--History--19th century
This thesis is a historical examination of the perception of Louisville as a southern city. The work begins with a discussion regarding Louisville's historical ties with the North and its acceptance as either a western or northern city. The thesis...
Accelerated life testing; Reliability (Engineering); Service life (Engineering)
This dissertation is focused on finding lower confidence limits for the reliability of systems consisting of Wei bull components when the reliability demonstration testing (RDT) is conducted with zero failures. The usual methods for the parameter...
Aim. Differences in the healing of demineralized and mineralized allografts have been reported but their significance has not been evaluated in ridge preservation studies. The primary aims of this study were to compare ridge preservation using a...
Aims. The primary aims of this randomized, controlled, blinded clinical trial were to
compare the hard and soft tissue response following either a connective tissue (CT) or
acellular dermal matrix (ADM) graft placed...
Several technical and economic obstacles currently hamper the industrial development of ethanol from biomass. One of the key bottlenecks is the slow kinetics of the enzymatic hydrolysis of cellulose, and the subsequent rate reduction as the...
Aims . The primary aim of this study is to compare the clinical and histologic results of a flap vs. a flapless technique of ridge preservation after 4 months of healing. Both groups received an intrasocket graft of demineralized bone matrix mixed...
Middle school teachers--Kentucky; Middle school students--Kentucky; Academic achievement; Teachers--Job satisfaction--Kentucky; School environment--Kentucky
This quantitative study focused on 760 Kentucky middle school teachers in 28 school districts across the state of Kentucky. The Pearson r was used to determine the relationship between the following variables identified in the study: (a) school...
Traditionally, fingerprint image acquisition was based on contact. However
the conventional touch-based fingerprint acquisition introduces some problems
such as distortions and deformations to the fingerprint image. The most recent
technology for...
