The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
Aims. The primary aim of this study was to compare esthetic outcomes for the Nobel Replace Standard implant vs. the Nobel Perfect Scalloped implant as determined by hard and soft tissue measurements and objective and subjective esthetic indices....
