The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
The use of monochloramines in the potable water supply industry has been selected as the disinfectant method of choice due to a longer term of effectiveness and less toxic by-products than the previous choice of chlorine. In spite of the benefits...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Elastomer degradation when exposed to chloraminated potable water is dependent on a number of poorly understood factors. Temperature and chloramine concentration are both believed to play roles, however, they have not been adequately defined. In...
Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
The airline regulatory communities are interested in methods that can access degradation in the polymer insulation of aging aircraft wiring. This study investigates the response of bulk polymer films and aircraft wiring under indentation; changes...
Nosocomial infections; Catheterization--Complications; Drug resistance in microorganisms
Catheters represent an essential part of the management of critically and chronically ill patients. However, their use is often plagued by catheter related blood stream infections (CRBSIs), which are associated with increased morbidity, hospital...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Nanostructured materials; Nanotubes; Nanoparticles; Drug delivery systems; Diagnostic Imaging
Nanomaterials have many intriguing applications in biology and medicine. Unique properties such as enhanced electrical properties, increased chemical reactivity and resistance to degradation, novel optical properties and comparable size to that of...
Complement, an early recognition system of innate immunity that senses local tissue damage and infection, cross-talks with and regulates other signaling systems, including Toll-like receptor (TLR) pathways. In the context of periodontitis,...
Due to the overwhelming increase in open source code, off-the-shelf software packages, third party and vendor codes, along with the ease of getting information about hacking network security systems and attacking the well known holes in security...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
Posters; Billboard posters; Billboards; Prints; Lithographs; Planographic prints; Advertisements; Advertising; Exhibition posters; Exhibitions; Art exhibitions; Motion pictures; Erotic films; Erotica; Sex; Relations between the sexes; Lust;...
Lithograph billboard poster. "Koons followed up this poster with a series of explicit, human-scale, photo-based 'paintings' of the couple having sex. Characteristically, Koons asserted that his concerns were far removed from pornography. He...
Posters; Billboard posters; Billboards; Prints; Lithographs; Planographic prints; Advertisements; Advertising; Exhibition posters; Exhibitions; Art exhibitions; Motion pictures; Erotic films; Erotica; Sex; Relations between the sexes; Lust;...
Lithograph billboard poster. "Koons followed up this poster with a series of explicit, human-scale, photo-based 'paintings' of the couple having sex. Characteristically, Koons asserted that his concerns were far removed from pornography. He...
