The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Wheelchairs--Design and construction; Dogs--Equipment and supplies; Dogs--Health; Veterinary physical therapy
Hind limb paralysis may occur in dogs for a variety of neurological or musculoskeletal reasons. For dogs with limited mobility their lack of ability to ambulate can have a great impact on their physical and mental health. Canine wheelchairs can...
A class of RC active filters in which the DC offset of the operational amplifier (op-amp) is completely absent from the filter output [1]. Individual filter configurations (Low Pass, High Pass, Band Pass, Band Stop, All Pass) are discussed and...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
In order to satisfy customer expectations, a ground vehicle must be designed to meet a broad range of performance requirements. A satisfactory vehicle design process implements a set of requirements reflecting necessary, but perhaps not sufficient...
Computer arithmetic; Computer arithmetic and logic units; Computer algorithms
This research evaluates an innovative binary adder design and compares it against five standard adder designs. It begins with an algorithmic description of the five standard designs followed by the innovative design. It uses two metrics, speed and...
An investigation was made into the relative costs of excavation retention by two systems: conventional soldier pile-wale-tieback support, and support by soil nailing. The investigation included design of excavation supports by the two...
Microelectromechanical systems; Biotelemetry; Strains and stresses--Measurement
Lumbar arthrodesis or spinal fusion is usually performed to relieve back pain and regain functionality from ruptured discs, disc degenerative disease, trauma and scoliosis. Metal rods are often fixed to the spine with screws or hooks, while fusion...
Aortic Valve Bypass surgery has found renewed interest to researchers due to its application in high-risk patients with severe aortic stenosis. This therapy consists of construction of a conduit containing a bioprosthetic or mechanical valve from...
Musical pitch--Data processing; Sound--Recording and reproducing--Digital techniques
Many mathematical formulas and algorithms exist to identify pitches formed by human voices, and this has continued to be popular in the fields of music and signal pro-cessing. Other systems and research perform real time pitch identification...
Age-related macular degeneration (ARMD) and retinitis pigmentosa (RP) are the two leading causes of blindness in the world today. Despite enormous efforts and advances in clinical treatment of eye diseases, there is no established method or cure of...
Prints--Kentucky--Louisville--Exhibitions; Painting--Kentucky--Louisville--Exhibitions; Art quilts; Block designs; Screen process printing; Feminism and art
This thesis explores pattern juxtaposition using traditional American quilt block designs as the compositional basis for nine works pieced from screen printed paper. In the 1970s, the quilt was celebrated for its apparent connection to Modernist...
A decision support system (DSS) is a computer-based tool that extends an operator's cognitive abilities and makes him more effective in decision-making situations. This thesis discusses the characteristics and historical applications of decision...
The thesis focuses on improving the flowrate of the Knudsen gas pump. The Knudsen pump uses thermal transpiration as the driving mechanism to pump gas. It is a motionless gas pump as the pump does not require any moving actuators for pumping. The...
Heat pipes; Solar heating--Passive systems; Solar heating--Research; Solar energy--Research
The one dimensional heat transfer, thermal diode effect of heat pipes makes
them ideal for passive solar applications. Gains in a heat pipe passive solar wall are not
lost during cloud cover or periods of low irradiation. An experimental model was...
New products--Management; Consumer satisfaction; Marketing--Management
A constant flow of innovative products which meets the needs of customers and therefore is a monetary success for the inventing organization is important for the long term success of organizations, especially in modem dynamic markets. As resources...
The following thesis examines the relationship between site geology and ground motion amplification for medium sized earthquake events in the Ohio Valley area. This thesis also includes a Rapid Screening Guide that can be used to estimate...
City planning--Psychological aspects; City planning--Citizen participation
This dissertation examines the impact of complexity and familiarity on visual preference for two content domains defined as Neo-Traditional and Modern. This research has five main themes: (1) To determine if there is a method for community design...
The process of designing the settings and lighting for a show is an adventure; it's a story that has the normal components of any good story, a beginning, middle and end. There is tension, conflict, climax and resolution. It contains characters who...
Children's literature in mathematics education; Mathematics--Study and teaching (Elementary); Problem youth--Education (Elementary); Mathematics--Remedial teaching
Nationally, there are increasing numbers of students who are at-risk for academic and/or social failure (U.S. Department of Education, 2009). In an attempt to address this trend, the 2004 reauthorization of the Individuals with Disabilities...
