Das Leben "Des jungen Goethe" sollte eigentlich bis zur Zeit seiner vollen Reife zum Alter von etwa dreissig Jahren handeln, mit Hinzuziehen von allen Zustaenden, Ereignissen, und Leuten, welche irgend einen Einfluss bis dahin auf sein...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Bcl-2 proteins are major regulators of cellular responses to various apoptotic stimuli. Among them, overexpression of the anti-apoptotic BcI-2 protein BcI-xL modulates organelle-specific apoptotic pathways. To understand the mechanisms by which...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which
are detectable in the serum of all American adults. Amongst PCB congeners,
PCB 153 has the highest serum level. PCBs have been dose-dependently
associated with suspected...
The ability of L. pneumophila to cause disease depends on its replication in alveolar macrophages. Infectivity and the expression of various virulence traits is triggered at post exponential growth phase. We show that unlike quiescent macrophages,...
Character portrait of a young boy costumed in clerical vestments. He holds his hands together in prayer. Inscription on mount, lower center: With love to Mrs. Macauley. Er Lawshe. Title supplied by cataloger.
The remodeled Hotel Hacker near the corner of College and Center Streets in Oneida. Some male students from Oneida Baptist Institute stayed at this hotel paying $1.50 per week for room and board. The hotel was run by Andy "Br'er Rabbit"...
Andy "Br'er Rabbit" Hacker's home in 1906, which later became the Hotel Hacker. Center Street runs behind the house. Taylor B. Britton's house sits at the corner of Second and Center, and "Uncle Nat" Burn's large house is...
Andy "Br'er Rabbit" Hacker, his second wife "Sis Rabbit" and son Bob. Sis had two brothers who were preachers, Andy and Tom Murrell. Bob Hacker graduated from Oneida in 1925.
University of Louisville--Football; University of Louisville--Sports; University of Louisville--Students; Football players;
The University of Louisville football team of 1921, in their football gear. A couple of the men wear helmets. Organized football teams were officially established at U of L in 1912. Most of U of L's football players at the time were medical...
