The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Psychic trauma in art; Psychoanalysis and art; Art--Psychological aspects; Salomon, Charlotte, 1917-1943. Leben oder theater?
This thesis explores the presence of the dialectic of trauma in Charlotte Salomon’s magnum opus, Life? or Theatre?, a series of more than seven hundred paintings created during her time in exile in France between 1941 and 1942. In this series,...
Emigration and immigration--Government policy; United States--Emigration and immigration--Government policy; Russia--Emigration and immigration--Government policy; Germany--Emigration and immigration--Government policy
This exploratory study proposes a model for examining the evolutionary nature of immigration policy, the Cappiccie Lawson Evolution Immigration Model (CLEIM). The model was applied to the United States, Germany, and Russia to provide a broad...
The following thesis examines the relationship between site geology and ground motion amplification for medium sized earthquake events in the Ohio Valley area. This thesis also includes a Rapid Screening Guide that can be used to estimate...
This thesis reports the reactivity of the rhenium-thiolate complex, tris(2-diphenylphosphinobenzenethiolato)rhenium(III), [Re(DPPBT) 3 ] ( 1 ) and its oxidized derivatives with ethylene. The reactivity has been studied by electrochemical,...
This thesis is examines the imperial attachment to the Suez Canal from 1875 to 1956. It begins with the canal share purchase by the Disraeli Government and ends with the Suez Crisis. Traditional scholarship views relations between the Britain and...
Lewis, M. G. (Matthew Gregory), 1775-1818--Criticism and interpretation; Lewis, M. G. (Matthew Gregory), 1775-1818. The monk
When Ambrosio in Matthew Lewis's 1796 gothic masterpiece, The Monk , signs a contract relegating his soul to Satan and eternal damnation, he has reached the culmination of 442 pages of mental anguish, of his self wrestling with his conscience to...
Marginal inference for waiting times in multi-stage time-to-event models is complicated by right censoring of observations as well as the prior history of events in the model. In general, complications arise due to the evolution of the censoring...
Qubbat al-Sakhrah (Mosque : Jerusalem); Jerusalem--Buildings, structures, etc.; Abd al-Malik ibn Marwan, Caliph, 642-705
This thesis provides a hypothesis as to why the Dome of the Rock
was built. I examine various scholarly theories concerning the
construction of the first notable work of Islamic architecture, which was
built in Jerusalem during the last decade of...
There has been an increasing use of Unconventional Therapies in the past decade. These refer to healthcare interventions representing either a compliment or alternative to traditional medicine to which many people have turned in hope of attaining a...
Research--Moral and ethical aspects; Sociology--Research--Moral and ethical aspects
This dissertation is a comparative theoretical analysis of human rights, research ethics and human subjects protection. The history of human rights is a long one, but for the sake of immediacy and focus, the author will limit the discussion to...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
Child maltreatment touches almost 700,000 children annually. The effects
of child maltreatment range from micro-level consequences, such as behavior
problems and mental health issues, to mezzo-level consequences, such as
increased child...
This quantitative dissertation examines risk assessment and recidivism of child maltreatment to determine the relationship between child protective services provided by the Kentucky Department of Protection and Permanency and risk of harm. A chart...
Feminism in art; Art, Mexican; Women in art; Art and society--Mexico
This dissertation outlines a theoretical model for contextualizing contemporary
women's art practice in Mexico within the profound socioeconomic and political events
that have taken place since 1968, characterized by the steady breakdown and...
Amish--Books and reading; Amish--Ohio--Social life and customs; Literacy--Ohio
Following in the tradition of scholars who treat literacy in context such as Deborah Brandt, Shirley Brice Heath, and David Barton and Mary Hamilton, I conducted my dissertation research not in an academic classroom but in the valleys of Hanley, a...
Christian leadership--Case studies; Rural churches--Kentucky; Clergy; School improvement programs; Educational leadership
This qualitative study sought to illuminate successful practices of a turnaround leader in a rural church that are applicable cross-contextually, so as to inform the leadership efforts of various organizations seeking to reproduce organizational...
Advancements in medical therapy have augmented resources available to
physicians to treat disease and, because of this, spending on prescription drugs
has doubled in the past decade. Increasingly, clinical trials are demonstrating the
benefits of...
