T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Slavery and the church--Kentucky--Louisville; Slavery--Kentucky--Louisville; Louisville (Ky.)--Church history
In the one hundred and forty years of Louisville's existence, it has grown from a log cabin settlement with no churches to a city with 269 churches and church property valued at over $30,000,000. It is impossible to measure the moral and religious...
Edgard Varese began composing "Deserts" in 1949 and completed it late in 1954. Scored for fifteen instruments, five percussionists and two tapes of organized sounds, "Deserts" comprises acoustic instrumental music and sections...
Jin, Ha, 1956-; Masculinity in literature; Chinese literature--20th century; Sex (Psychology) in literature
This dissertation consists of readings of three selected novels by Ha
Jin-Waiting, The Crazed, and A Free Life. These novels cover three historical
periods of Contemporary China under the rule of the Communist Party in
sequence-the Mao's era...
Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
This dissertation explores the physical and biological factors that control zooplankton population growth rates in the Ohio River (USA). I employed both observational studies and a mesocosm experiment to ascertain zooplankton population and...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
This thesis is about graphic representations of violence and subjectivity. Simply stated, the violence in many recent horror films is motivated by a nihilism resulting from frustration with the inadequacy of contemporary subjectivity. I want to...
Shen, Fu, 1763-ca. 1808. Fu sheng liu ji; Shen, Fu, 1763-ca. 1808--Criticism and interpretation; Chinese literature--Qing dynasty, 1644-1912--History and criticism; Conduct of life in literature
This study endeavored to provide a new path to understand Fusheng liu
ji (Six Chapters of a Floating Life) by Shen Fu in the middle of the Qing
Dynasty (1636-1911). Shen Fu recorded his love story with his wife Chen Yun and his life as a Chinese...
Women on television; Animated television programs--Social aspects; Women in popular culture
Utilizing the criteria for unruly women established by Kathleen Rowe, this work engages with current television scholarship on animated sitcoms in order to come to an understanding of how unruliness as a category of behavior and embodiment is...
This thesis is an economic and historical examination of Keeneland racetrack in Lexington, Kentucky. The material commences with a historical overview of the role of sport and recreational activities in the United States. Putting sport and leisure...
The purpose of this dissertation is to suggest that peace is an idea that changes throughout the history of the west, rather than to show how nations may achieve peace or to define what it is. It begins as a concept the power brokers refer to or...
This paper explores issues of identity and difference in art and its institutions through a historiographic study of two landmark exhibitions, "The Other Story: Afro-Asian Artists in Post-War Britain" (1989) and the 1993 Whitney Biennial....
Cadman, S. Parkes (Samuel Parkes), 1864-1936; Radio in religion--United States--History; Religious broadcasting--Christianity--History; Religious broadcasting--United States--History; Christianity--United States--20th century
S. Parkes Cadman (1864-1936), a Christian minister at Central Congregational Church in Brooklyn, New York from 1901 to 1936, was a popular religious figure in interwar America. From 1924 to 1928, Cadman served as president of the Federal Council of...
Military nursing--History; World War, 1914-1918--Women; World War, 1914-1918--Medical care; Women and war--History--20th century
World War I resulted in the deaths of over 8,500,000
military personnel and in addition, millions of civilians.
There were not enough doctors to provide the necessary
medical care for the masses of seriously sick and wounded,
and other than in...
