Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
Hepatitis C virus--Research; Interferon--Therapeutic use; Adenosylmethionine
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the United States and is a huge burden on the US healthcare system. The FDA-approved traditional standard of care for HCV is pegylated interferon-alpha (lFNα) combined...
The immune system is of profound importance for host survival due to its ability to clear many acquired diseases. In case of infections and cancer, disease arises due to under-performance of immune system. Whereas in autoimmunity and...
Hurricane Katrina, 2005--Psychological aspects; Writing--Psychological aspects; Psychic trauma in literature; Crisis in literature
The discourses of "trauma" and "post-trauma" have become pervasive in representations of life as it is lived in contemporary globalized culture. As new media technologies make the world more accessible, we become accustomed to...
INTRODUCTION: Heart failure is a major and growing public health concern. Although heart failure has been considered an inexorable and progressive disorder, emerging evidence suggests that some patients may have reversible left ventricular...
This thesis describes 1) the kinetics of vapor phase place exchange reactions on films of gold monolayer protected clusters (Au MPCs) to alter the functionality of the Au MPCs, 2) applications of the reaction for altering chemiresistive sensing...
Cumberland Falls State Park (Ky.); Historic preservation--Kentucky
This thesis is an examination of Louisville Times editor Tom Wallace's fight to prevent the construction of a hydroelectric dam at Cumberland Falls, Kentucky between 1926 and 1931. By mining Wallace's recently cataloged personal papers, this study...
Marconi, Guglielmo, marchese, 1874-1937; Radio broadcasting--Social aspects
This dissertation is a rhetorical analysis of Guglielmo Marconi's wireless. Texts surrounding the invention reveal intersections between technology and society and communicate information about the wireless through tropes of progress. The wireless...
Interactions between chemokines and their receptors are involved in organ- specific homing and propagation of metastatic breast cancer (BrCa) cells. BrCa cells express higher levels of CXCR4 and CXCR7 mRNA and cell surface protein, than normal...
The goal of this longitudinal, multilevel study was to develop a better understanding of poor renter households' mobility patterns by identifying the relative importance of individual and contextual variables. Variability in neighborhood poverty...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
Current high-throughput gene expression experiments have a straightforward design of examining
the gene expression of one group or condition relative to that of another. The data is typically
analyzed as if they represent strictly intracellular...
Spinal cord--Wounds and injuries; Stretch (Physiology)
An increasing amount of healthcare resources is used for the treatment and prevention of contractures in patients with spinal cord injury (SCI), with stretch and passive movements remaining the most prominent intervention methods. The results of...
Church buildings--Spain; Church architecture--Spain; Spain--History--711-1516
This dissertation examines the architectural evidence in the ongoing debate surrounding the demographical and political value of the shifting Iberian frontier of the tenth through twelfth centuries. In particular, it seeks to problematize the...
Energy independence requires that the nation reduce its dependence on foreign oil imports. This can be achieved through electrification of transportation vehicles if proper battery technology can be developed. In addition, the renewable energy...
Rising environmental concerns due to our rising population ad energy demand along with our excessive dependence on fossil fuels has created an urgent need to find clean, renewable and carbon free source of energy. Photoelectrochemical (PEC) water...
Autistic children--Education; Mainstreaming in education; Teachers--Attitudes; Inclusive education
The purpose of this research study was to examine the relationship between the
attitudes of public school teachers and the inclusion of students with autism in the general
education classroom highlighting individual teacher characteristics that...
The use of franchise advisory boards, typically composed of franchisees and
franchisor representatives, is common practice in domestic and international franchise
systems. Because effective board collaboration requires teamwork, understanding...
Many businesses have poor IT infrastructure and are in need of a major overhaul. University of Louisville Properties (ULP), in particular, needed the ability to share files between staff, backup data, secure data, and eliminate viruses and malware....
