The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Nuclear Factor of Activated T-cells (NFAT) is a calcium-responsive transcription factor that orchestrates immune response and cardiovascular development. NFAT is also present in neurons and glia from the Central Nervous System (CNS) where it...
Many species of fungi undergo a dimorphic transition to switch from a unicellular yeast-like growth form to a filamentous growth form. Ustilago maydis undergoes such a transition, in response to successful mating events and subsequent host cues, to...
Quorum sensing (Microbiology); Cellular signal transduction; Bacterial genetics
Quorum sensing in the oral pathogen Aggregatibacter actinomycetemcomitans is dependent upon the soluble signaling molecule AI-2, but it is not known how the initial detection of AI-2 is coupled to the downstream regulation of gene expression that...
Mycobacterium tuberculosis causes the often-fatal infectious disease Tuberculosis, and infects approximately one third of the world's population. Gaining a better understanding of how these bacteria regulate gene expression for intracellular...
Dimorphism is a highly conserved process in fungi in which a transition between a unicellular, yeast-like growth form and either a unicellular or multicellular, filamentous growth form occurs in response to several different environmental cues. The...
Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk...
Nitrile hydratase (NHase) is a metalloenzyme that contains a non-heme iron (III)
or non-corin cobalt (III) in a non-redox active role. NHase is used as biocatalyst in the
industry for the hydrolysis of nitriles to arnides. The trivalent metal ions...
We are more likely to "hurt the one's we love" than we are complete strangers (cf. R. Miller, 1991, 1997). Early in dating relationships, partners appear to me more likely to manage their impressions to present themselves as better than...
Inflammatory Bowel Disease (IBD) is a chronic illness with the potential to affect many areas of one's life through painful physical symptoms and psychological distress. Despite the debilitating nature and increasing prevalence of IBD, there is...
Group portraits; Portrait photographs; Actresses; Women; Costumes; Posing; Families
Group portrait of three Vokes sisters (Victoria, Rosina, and Jessie), who, with Fred and Fawdon Vokes, wrote and performed sketches as the Vokes Family in the 1880s. They are wearing dark, winter-weight dresses and hats. They performed "The...
Group portraits; Portrait photographs; Actresses; Women; Costumes; Posing
Group portrait of three Vokes sisters (Victoria, Rosina, and Jessie), who, with Fred and Fawdon Vokes, wrote and performed sketches as the Vokes Family. They are wearing striped dresses with pinafores and wide-brimmed hats. These costumes may...
Sculpture; Mixed media; Maps; Recycling; Conservation of natural resources; Economics; Economic & political systems; Political issues; Politics & government
"It was not until the end of the 1970s, in the work of a new generation of sculptors including Tony Cragg, Richard Deacon, Anish Kapoor, and Bill Woodrow, that the sculptural object as such, in relation to human or urban themes, reassumed...
Prints; Screen prints; Allusions; Death; Disasters; Tragedies; Accidents; Automobiles; Vehicles; Dead persons; Wounds & injuries; Voyeurism; Social aspects; Social classes
"The use of serial repetition here, as in other early Warhol works, relates interestingly to Minimalist uses of repetition. The reciprocally ironic relation between Warhol and the Minimalists came to a head in 1964. Warhol exhibited a series...
