This thesis looks at the optimization of fluid flow and mass transfer using computational fluid dynamics (CFD) in a micro fluidic coulter counter. CFD will be used to solve equations of fluid flow and mass transfer to see how molecules within the...
QSOs, providing distant, luminous sources of radiation, provide a means to detect gas by absorption in the interstellar and intergalactic medium. Of particular interest to astronomers studying metal line systems in lines of sight to QSOs are the...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Heart--Diseases--Diagnosis; Diagnostic imaging; Magnetic resonance imaging; Imaging systems in medicine
Many cardiac diseases, such as myocardial ischemia, secondary to coronary artery disease, may be identified and localized through the analysis of cardiac deformations. Early efforts for quantifying ventricular wall motion used surgical implantation...
Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of...
Railroads--Virginia--History--19th century; United States--History--Civil War, 1861-1865--Transportation; Virginia--History--Civil War, 1861-1865
This thesis is an examination of the Virginia railroad system during the Civil War. Using extensive and primary secondary sources, the thesis argues that the Virginia General Assembly, the Confederate Government under Jefferson Davis, and the...
Electric power production--Data processing; Electric power distribution--Data processing
The purpose of this project was to analyze the ordering policies for a distribution system. The company has one central distribution center and nineteen branch warehouses spread throughout the country. Each branch warehouse can order product lines...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Human adenoviruses (Ads) can infect and replicate in cells at different cell-cycle stages. Ads with the E1 B55K deletion preferentially replicate in cancer cells and cause oncolysis. Our laboratory has previously shown that the Ad E1 b gene is...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
Shelley, Percy Bysshe, 1792-1822--Criticism and interpretation
The most striking quality of Shelley's poetry meets our attention once, in the play of ever-changing emotion through his lines. When he called himself "A pard-like Spirit beautiful and swift," he characterized the spirit of his poetry,...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
Human being can easily acquire information by showing the object than reading the description of it. Our brain stores images that the eyes are seeing and by the brain mapping, people can analyze information by imagination in the brain. This is the...
This treatise is not intended to cover the whole field of Rural Sociology. It deals briefly with the more important phases of the subject. Perchance many important problems have been omitted which the reader will call to mind. This will go to show...
Diabetic cardiomyopathy (DCM) is a common complication leading to accelerated cardiovascular failure in diabetic patients. Even though the exact mechanism(s) behind this disease still remain unclear, research from several laboratories including our...
Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
A careful perusal of Shakespeare’s works leads to one outstanding conclusion. Shakespeare was preeminently interested in words, as such. His every play shows a painstaking attention to words in their various shades of meaning. It is our interest...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
Nanoparticles; Drug delivery devices; Gene therapy
The properties and broad applications of nano-magnetic colloids have generated much interest in recent years. Specially, Fe304 nanoparticles have attracted a great deal of attention since their magnetic properties can be used for hyperthermia...
