The immune system is of profound importance for host survival due to its ability to clear many acquired diseases. In case of infections and cancer, disease arises due to under-performance of immune system. Whereas in autoimmunity and...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Educational leadership; School improvement programs; School management and organization
This study examines how two schools utilized elements of distributed leadership to implement strategies from a reform intervention for whole school and classroom improvement planning from data. The notion of distributed leadership was refined in a...
Anxiety in adolescence; Parent and teenager; Parenting
This dissertation examined the prediction of anxiety symptoms over time during
developmentally significant periods - the transition to middle school (12 years old) and
the transition to high school (15 years old). Specifically, relationships...
Three research questions made up the focus of the study. First, after controlling for demographic variables of age, gender, and tenure in organization, to what extent does trust in leader (nurse manager) relate to job satisfaction? Second, after...
Educational leadership--Kentucky; Educational accountability--Kentucky; Educational change--Kentucky; School improvement programs--Kentucky
In 1983 the National Commission on Excellence in Education released A Nation at Risk, which triggered an extended era of school reform culminating in today's accountability movement. In Kentucky the school improvement process, in which principals...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
Self-efficacy; Psychological abuse; Identity (Psychology); Women college students--Mental health
The current research proposed that psychological abuse within an intimate relationship erodes one's self-efficacy and aimed to demonstrate a negative relationship between past psychological abuse and how one reacts to a challenge. It was...
Copper--Physiological effect; Copper in the body; Heart--Hypertrophy
Previous studies have shown that copper (Cu) supplementation at physiologically relevant levels reverses cardiac myocyte hypertrophy induced by phenylephrine (PE), and that this effect was VEGF-dependent. Yet, the amount of VEGF in the media was...
Educational tests and measurements--Kentucky; Educational accountability--Kentucky; School improvement programs--Kentucky
High-stakes accountability, standards for improvement, global perspectives, and social considerations are re-defining the educational process. These powerful forces shake foundations and traditions, restructure organizational expectations, and...
English language--Study and teaching--Foreign speakers; English language--Study and teaching (Elementary school); Parent-teacher relationships; Home and school; Academic achievement
This dissertation study examined the relationships between school support (i.e.,
student services and family outreach), parental school involvement, and academic and
social-emotional outcomes for children who are English Language Learners...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
This thesis is based on experimental work on electrochemically mediated charge transfer effects on Single-walled carbon nanotube bundles. The study of these effects are very important towards understanding the sensitivity of gases on nanostructures...
Reperfusion of the ischemic lung causes pulmonary arteriolar vasoconstriction and reduces alveolar perfusion. Lung ischemia-reperfusion (IR) injury leads to platelet and leukocyte activation which could contribute to decreased alveolar perfusion...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
Background. Progression of alcoholic liver disease (ALD) is associated with an increase in fibrin extracellular matrix (ECM) and inflammation. Previous studies have shown that this accumulation of fibrin in ALD is mediated by impaired fibrinolysis....
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
