Educational change--Kentucky--Grant County; Student adjustment; High school students; Middle school students
This study investigated the impact of articulation activities and the extent to which the Grant County Kentucky school district operated as a learning organization during the implementation of a research-based middle to high school student...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
INTRODUCTION: Heart failure is a major and growing public health concern. Although heart failure has been considered an inexorable and progressive disorder, emerging evidence suggests that some patients may have reversible left ventricular...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
Drug resistance in microorganisms; Salmonella typhimurium
Salmonella enterica serovar Typhimurium is an enteric pathogen capable of infecting
a wide range of hosts. The manner in which this pathogen is able to interact with its
host is difficult to define, as is the case with most microbes. Through the...
Menthol has been regularly utilized as a treatment in sports related injuries for many years, yet little is known about its physiological interactions or its effect on performance. Our previous study indicates that topically applied menthol may...
Reperfusion of the ischemic lung causes pulmonary arteriolar vasoconstriction and reduces alveolar perfusion. Lung ischemia-reperfusion (IR) injury leads to platelet and leukocyte activation which could contribute to decreased alveolar perfusion...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Periodontal disease arises from excessive host inflammatory responses to the tooth-associated microbial biofilm, known as dental plaque. Severity ranges from superficial inflammation of the gingivae (gingivitis) to extensive destruction of...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Epithelial Ovarian cancer (EOC) is the leading cause of gynecological cancer death in the USA. Recurrence rates are high after front-line platinum chemotherapy and most patients eventually die from platinum-resistant disease. P53 plays an important...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
