Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
The goal of this thesis is to determine if neuropsychiatric features can differentiate parkinsonian patients with: tauopathies from those with alpha-synucleinopathies and explore caregiver distress. Three hundred and four patients (62 with...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
