This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
Metastasis is a complex process requiring directed migration of metastatic cells to favorable microenvironments. Increased CXCR4 expression has been implicated in more invasive, aggressive and metastatic tumor phenotypes and poor patient survival...
The fundamental importance of a definite knowledge of the quantity of each amino acid yielded by the several food proteins justifies the expenditure of much effort in studying the analytical methods in order that these may be improved or their...
Chlamydia trachomatis is an obligate intracellular pathogen that utilizes a type III secretion system to enter mammalian cells and establish an intracellular niche. TARP, the translocated actin recruitment protein, is a chlamydial invasion protein...
Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...
Recent advances in high throughput methodologies offer researchers the ability to understand complex systems via high dimensional and multi-relational data. One example is the realm of molecular biology where disparate data (such as gene sequence,...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
The study of the relationship between chemical constitution and physiological effect embraces many very interesting problems which are, however, frequently difficult to solve. In the investigation of any drug the first step is to determine the...
Gas manufacture and works; Carbon dioxide mitigation; Natural gas
The separation of carbon dioxide from natural gas is of great interest from the environmental and energy perspective, respectively. From the environmental point of view, capturing CO2 effectively from power plants can have a positive impact on...
Acridine is a compound that has a ring system similar to anthracene except that one of the CH groups is replaced by a -N- group. It is possible for this compound to have desmotropic forms as those that follow. When an amino group is present in the...
The separation of C02 from light gases is a very important environmental and energy issue. The state-of-the-art process for the purification of C02 uses amine adsorption, which is a complex, and costly. Membrane technology is far less expensive...
