c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Aims. The primary aim of this randomized, controlled, blinded clinical trial was to compare the clinical and histologic results of ridge augmentation comparing a cancellous block allograft to a particulate mineralized freeze dried bone allograft...
Mathematics teachers--Training of; Student teaching; Mathematics teachers--In-service training
Teacher candidates enter teacher preparation programs with grounded beliefs
about teaching and learning. These beliefs are especially problematic in the area of
mathematics, as they hinder instructional decisions (Karp 1988, 1991; Kolstad &...
The impact of socioeconomic status on the diagnosis, treatment, survival, and overall quality of life in persons with cancer has been well documented. Yet, many studies overlook the relevance of socioeconomic factors when measuring the impact of...
Shakespeare, William, 1564-1616; Great Britain--History--16th century; Great Britain--History--17th century
Of all the arts drama is the most democratic. Other forms of artistic and aesthetic expression, literature, music, painting, may be cultivated in solitude. Not so the drama. It is demanded by the public; produced for the public and unless it is...
Portraits; Men; Physicians; Medical equipment & supplies
Dr. Challon G. Forsee of Louisville, Kentucky wearing a physician's gown, holding a bottle of medicine. The photograph has a few blemishes and discoloration. Attached to back of image: Louisville and Nashville Railroad Company; Office of General...
Bookplates; Labels; Young Women's Christian associations
Ornate decorative border featuring text, a scroll, and a triangle. Lettering near the top reads "YWCA." On the scroll is the name "Carrie McGill" and the word "Memorial." Near the bottom is the abbreviation...
Mary Margaret McBride hosted a popular radio program starting in 1934. She advertised products she had personally approved. Jean Thomas apparently distributed some of these products to people living in remote areas in eastern Kentucky. Here, Jean...
Mary Margaret McBride hosted a popular radio program starting in 1934. She advertised products she had personally approved. Jean Thomas apparently distributed some of these products to people living in remote areas in eastern Kentucky. Here, Jean...
Mary Margaret McBride hosted a popular radio program starting in 1934. She advertised products she had personally approved. Jean Thomas apparently distributed some of these products to people living in remote areas in eastern Kentucky. Here, Jean...
Mary Margaret McBride hosted a popular radio program starting in 1934. She advertised products she had personally approved. Jean Thomas apparently distributed some of these products to people living in remote areas in eastern Kentucky. Here, Jean...
Mary Margaret McBride hosted a popular radio program starting in 1934. She advertised products she had personally approved. Jean Thomas apparently distributed some of these products to people living in remote areas in eastern Kentucky. Here, Jean...
113 maps, plus legends and information about publishers Louisville Title Company, Inc. (a real estate insurance and mortgage company), representing the city of Louisville, Kentucky and surrounding county ca. 1913, with color coding for railroads,...
Color map, with Street Index, of Louisville, Kentucky, compiled in 1936. Verso includes lists of public halls, blocks and buildings; places of amusement (theaters, private parks, etc.); subdivisions; monuments; clubs; hospitals, institutions, and...
Original sixteenth century leaf from a commentary or writings about the text of the Qur'an written on handmade paper. Followers of Islam find the Qur'an to be the literal word of God, revealed through the prophet Muhammad and containing all things...
An original manuscript leaf from a late sixteenth century or early seventeenth century Persian Qur'an, written and illuminated circa 1570-1630 on handmade paper. The Qur'an or Holy Koran is the key religious text for Islam. Followers of Islam find...
