Bioinformatics; Breast--Cancer--Treatment; Medical care--Data processing
Statistical models have been the first choice for comparative effectiveness in clinical research. Though effective, these models are limited when the data to be analyzed do not fit the assumed distributions; which is mostly the case when the study...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
Polymorphisms in the adrenergic receptor beta-2 (ADRB2) gene have been studied in relation to risk of Type 2 diabetes and obesity, but few studies have investigated associations with breast cancer. The purpose of this research was to evaluate the...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
While investigating estrogen response element (ERE) binding properties of Erα in de-identified human breast cancer extracts, additional proteins were observed that recognized ERE sequences (ERE-BP). In order to unravel the apparent role of these...
Cancer patients show circadian disruption that increases as disease progresses. Disrupted endocrine and activity rhythms predict early metastatic cancer mortality. Effects of psychological versus biological factors on rhythms are unknown, as are...
Interactions between chemokines and their receptors are involved in organ- specific homing and propagation of metastatic breast cancer (BrCa) cells. BrCa cells express higher levels of CXCR4 and CXCR7 mRNA and cell surface protein, than normal...
Breast--Cancer--Diagnosis; Medical screening; Breast--Radiography; Mobile hospitals
This study used the de-identified breast cancer screen data which recorded the
information of 58231 screens and 22534 participants with different background. The
analysis of disparities on age, ethnic, health insurance and screen location has been...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
The application of carbon nanotubes (CNTs) has captivated the curiosity of today's experts due to the escalating potential in the field of electronic detection of biomolecules. Their extreme environmental sensitivity and small size make them ideal...
Mishaps in prenatal development can influence mammary gland development
and, ultimately, affect susceptibility to factors that cause breast cancer. This research was
based on the underlying hypothesis that maternal dietary composition during...
Mary, Blessed Virgin, Saint--Art; Breastfeeding in art
This dissertation is an analysis of Italian late medieval and Renaissance peoples’ response to the Madonna lactans image. Although the images that comprise this type are similar in that Mary holds Christ at her breast, they vary widely in...
Nanoparticles; Imaging systems in medicine; Imaging systems in biology
Gold nanoparticles (GNPs) have shown beneficial properties for biomedical use, e.g., their non-toxic nature and surface properties for easy modification. Upon receiving light, they generate a strong surface plasmon field, which can alter the...
In recent years, a number of computational and statistical problems for identifying SNP-SNP interactions in high dimensional survival data have been studied, and several data mining approaches have been proposed. However, the relative performance...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...
Kore: "Found at Merenda (ancient Myrrhinous), Attica, in 1972. […] Funerary statue. Found in a pit in the cemetery of Myrrhinous together with kouros [of Merenda] (inv. no. 4890). Preserved in excellent condition. The girl is depicted...
Kore: "Found at Merenda (ancient Myrrhinous), Attica, in 1972. […] Funerary statue. Found in a pit in the cemetery of Myrrhinous together with kouros [of Merenda] (inv. no. 4890). Preserved in excellent condition. The girl is depicted...
Police; Buildings; Government facilities; City & town halls
Police officers in front of City Hall at 601 West Jefferson Street in Louisville, Kentucky. Officers in uniforms (with stars on the left breast) and high hats stand in rows in front of City Hall's pillars and stairs. Except for two men in a third...
