Ozone forecast models using nonlinear regression (NLR) have been successfully applied to daily ozone forecast for seven metro areas in Kentucky, including Ashland, Bowling Green, Covington, Lexington, Louisville, Owensboro, and Paducah. In this...
Polycyclic aromatic hydrocarbons; Fetus--Effect of tobacco on
Polycyclic aromatic hydrocarbons (PAH) are chemicals generated from the incomplete combustion of organic materials, including tobacco smoke. Some PAH are known to be mutagenic and carcinogenic in humans, and of concern for the fetus when women...
Human exposure to mercury has been shown to cause a number of adverse health outcomes, predominantly neurological effects. The developing fetus is most susceptible, and even low levels of exposure have been shown to produce nervous system deficits....
This dissertation describes galvanic exchange of silver (Ag) nanostructures with PdCl42- in 1) various PdCl42- concentrations, 2) the presence of 0.1 M cetyitrimethylammonium bromide (CTAB), and 3) the presence of 0.1 M potassium bromide (KBr). It...
Oxidative stress-induced immunosuppression could be due to a decrease in CD4 + T lymphocyte activation or proliferation. 4-Hydroxynonenal (HNE), an end product of lipid peroxidation, and its protein adducts act as markers of oxidative stress. In...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
Enzymatic hydrolysis is an important, but time limiting step in the process of converting biomass into ethanol. High solids concentrations are desired in order to minimize reactor size and achieve a higher concentration of glucose in the end...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Few previous studies have compared microbial communities in subterranean and surface environments. Chemical analyses used to characterize the surface and cave microbial environments indicated limited exchange between surface and subsurface waters....
No current microfabrication technique exists for producing room-temperature, high-precision, point-to-point polymer nanofibers in three dimensions. Producing rounded structures in a third dimension is particularly difficult to accomplish with...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
Intelligent transportation systems; Air quality; Air--Pollution
Environmental or air quality impacts of Intelligent Transportation Systems (ITS)
are very difficult to measure. Some researchers have attempted to quantify the effects of
individual ITS application on emissions; yet, the effects of ITS as a whole...
In the electronic and microfabrication industry, die separation is one of the most critical steps in producing an undamaged, stand-alone micro-scale device. For silicon based devices, it is the predominant step governing resistance to die failure...
Vascular injury and chronic arterial diseases such as atherosclerosis and restenosis result in exposure of vascular smooth muscle cells (VSMCs) to increased concentrations of growth factors triggering a change from a contractile to a synthetic...
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
This study explores four economic development theories – classical location theory, human capital theory, agglomeration economies theory and creative cities theory, and their effectiveness in explaining the spatial distribution of high tech...
Menthol has been regularly utilized as a treatment in sports related injuries for many years, yet little is known about its physiological interactions or its effect on performance. Our previous study indicates that topically applied menthol may...
Stream riparian zones are ecotones between terrestrial and aquatic environments. Studying these areas in urban environments is important since they lie adjacent to stream water supplies. I conducted a study of riparian woody and groundcover...
