N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Type 2 diabetes presents a public health crisis and a global pandemic. Successful management of diabetes requires engagement in a daily regimen of self-care behaviors to achieve optimal glycemic control and to reduce the severity of...
Persons living with chronic pain encounter a host of physical and psychosocial problems resulting in a loss of quality of life and increased disability. The construct of avoidance has been proposed as a mechanism by which these changes in...
In the United States substance abuse takes a toll that is costly in both economic and human terms. In 2005 we paid 467.7 billion dollars to address the consequences of substance abuse, and each year we have lost an estimated 537,000 of our fellows...
The importance of physical activity in preventing disease and promoting health is increasingly evident in health outcomes research. Although most adults in the U.S. have initiated exercise programs at some point in their lives, research suggests...
Social anxiety is prevalent and debilitating. Contemporary models of social
anxiety posit that negative, self-focused thought aids in the maintenance of social anxiety
symptoms. Although these models emphasize in-situation cognition, recent...
Diabetes--Psychological aspects; Diabetes--Treatment; Diabetics--Mental health
The importance of maximizing self-management and quality of life is well documented in the diabetes literature. Although maintaining self-care is known to be important for individuals with type 2 diabetes, this is often difficult to maintain over...
Middle school education--Case studies; Academic achievement--Kentucky; Home and school--Kentucky
This dissertation is a case study of 109 students and their parents from a small rural, middle school community in Western Kentucky. It seeks to determine the interrelationships between conservative Protestant Parent Values (Parent Rural Values and...
Educational leadership; School improvement programs; School management and organization
This study examines how two schools utilized elements of distributed leadership to implement strategies from a reform intervention for whole school and classroom improvement planning from data. The notion of distributed leadership was refined in a...
Edgard Varese began composing "Deserts" in 1949 and completed it late in 1954. Scored for fifteen instruments, five percussionists and two tapes of organized sounds, "Deserts" comprises acoustic instrumental music and sections...
Pediatricians--Training of; Speech disorders in children
Children with general communication impairments as well as complex communication needs rely on pediatricians to prescribe the services of speech language pathologists. In light of this continuing and increasing need, it is important to ascertain...
Older people--Mental health; Philosophy of mind; Cognitive science--Health aspects
Declines in social resources and in the quality of interpersonal interactions have been observed in some older adults. Unawareness of ability is a clinical problem that has been found in some older adults with dementia, but has also been found in...
Senile dementia; Nursing home patients--Mental health; Anxiety in old age; Depression in old age
Dementia, depression, and anxiety are the most common psychiatric disorders among long-term care residents and, because dementia is associated with behavioral problems that can be difficult to manage, the growing number of long-term care residents...
Dentist and patient; Dentistry--Practice; Smoking cessation; Nicotine addiction--Treatment
Dentists can play a key role in helping patients quit tobacco use by providing tobacco cessation treatment (TCT) in their practice. Although the majority of dentists receive training in TCT, most do not provide adequate intervention. Many feel they...
Research literature acknowledges the importance of teacher leadership in school reform initiatives. The literature is replete with qualitative studies describing the experience of teacher leadership in its variety of enactments. The meager amount...
Dropout behavior, Prediction of; Nontraditional college students; College dropouts; Academic achievement
For more than 100 years, nearly half of all undergraduate students have failed to persist to degree completion (ACT, 2010; Tinto, 1993; U.S. Department of Education, 2008). To make matters worse, adult students have consistently been victims of...
Elementary school teachers--Kentucky; Mathematics--Study and teaching (Elementary)--Kentucky
This dissertation was a quantitative study with a sample of preservice elementary teachers from four universities in Kentucky. The purpose of this study was to investigate preservice elementary teachers' achievement goal orientations for learning...
This project examines the Conservation in Action series, twelve texts produced by the United States Fish and Wildlife Service (USFWS) from 1947-1957 and developed and written by Rachel Carson and other agency employees. She developed the series to...
Responding to research gaps in both cycling and women's rights history, the purpose of my thesis is to investigate conceptualizations of cycling in the 1890's suffrage press. I analyze six aspects of cycling in suffrage periodicals: advice and tips...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
