Cancer patients show circadian disruption that increases as disease progresses. Disrupted endocrine and activity rhythms predict early metastatic cancer mortality. Effects of psychological versus biological factors on rhythms are unknown, as are...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
Dimorphism is a highly conserved process in fungi in which a transition between a unicellular, yeast-like growth form and either a unicellular or multicellular, filamentous growth form occurs in response to several different environmental cues. The...
Short-term memory; Memory--Effect of sound on; Memory--Effect of noise on; Speech
The Irrelevant Speech Effect (ISE) is a phenomenon in which the presentation of
auditory materials (typically speech) impairs the serial recall of visually presented
materials, either digits or letters. Although this effect has been replicated in a...
Teacher-student relationships; Interaction analysis in education; Problem youth--Education (Secondary)
The interactions between teachers and students provide a venue for instructional delivery and ultimately student achievement in the school setting. However, not all students experience positive interactions with teachers in the typical classroom...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Gary Snyder's poetry conveys Zen states of consciousness through unconventional grammar and syntax. From his first book Riprap in 1959 to his last collection of poems, Mountains and Rivers Without End in 1996, he has confronted the challenge of...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...
Supervisory Control and Data Acquisition (SCADA) systems are used in almost
all industrial processes including use in the nation's critical infrastructure. The electric,
water, and gas industries are merely a few that rely heavily on the use of...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
Skeletal muscle is the most abundant tissue in our body that provides a structural framework and regulates important biological processes. It is also a primary reservoir of protein. Skeletal muscle maintains its structural and functional integrity...
Conducting polymers; Polymers in medicine; Myocardium
Hydrophilic and conductive characteristics in polymers are mutually exclusive of each other. Hydrophilic polymer properties allow absorption of water up to several magnitudes above their dry weight. However, due to their molecular structure, they...
Chapter I . Seven novel head-to-tail cyclic pentapeptides and pseudopentapeptides containing the arginine-glycine-aspartic acid (RGD) tripeptide motif were synthesized. All of the peptides were constructed using solid phase peptide synthesis....
