The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
From a computerized image analysis prospective, early diagnosis of lung cancer involves detection of doubtful nodules and classification into different pathologies. The detection stage involves a detection approach, usually by template matching,...
Nanoscience is not about products becoming smaller and smaller, but about new material properties being exploited for new and enhanced product applications. Liquid crystalline materials are one branch of "nanomaterials" that has promise...
INTRODUCTION: Heart failure is a major and growing public health concern. Although heart failure has been considered an inexorable and progressive disorder, emerging evidence suggests that some patients may have reversible left ventricular...
Russia (Federation)--Politics and government, 1991-
Every state, regardless of its size, faces a problem of spatial organization and distribution of its power over territory, particularly in times of the formation of its statehood and the establishment of the system of governance. The...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
Tobacco smoke is a strong and independent risk factor for several chronic systemic diseases and also increases susceptibility to a multitude of bacterial infections, including periodontal infections. Periodontitis is a chronic inflammatory disease...
In studying the culture of any people we learn that no group has been absolutely independent of influences from other people. No man indeed can say that he has attained anything of value absolutely by himself; an individual must give credit to the...
Alcoholic liver disease (ALD) ranks among the major causes of morbidity and mortality in the world and effects millions of patients each year. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which progresses...
Background: Helicobacter pylori (Hp) establishes life-long gastric infection in billions of humans, and is often responsible for diseases such as peptic ulcer and gastric cancer. Cumulative actions of genetic drift and natural selection over...
This study focuses on the variation in structural response to synthetic ground motions derived from the latest attenuation models developed for the Central Eastern United States (CEUS) and used by the USGS to develop the latest edition (2008) of...
Motivation (Psychology); Psychology and religion; Faith--Psychology
Religious motivation is a construct that has been the focus of decades of research. The "Religious Orientation Scale" (ROS) and variations of it, including the "Age Universal Intrinsic-Extrinsic Scale-12" (AUIES-12), are the...
Medical care--Decision making; Decision making--Simulation methods
A variety of methodologies have been employed for decision making related to the treatment of diseases/injury. Decision trees are a functional way in which to examine problems under uncertainty by providing a method to analyze decisions under risk...
Educational leadership; School improvement programs; School management and organization
This study examines how two schools utilized elements of distributed leadership to implement strategies from a reform intervention for whole school and classroom improvement planning from data. The notion of distributed leadership was refined in a...
Computer vision; Pattern recognition systems; Human face recognition (Computer science)
Humans have the uncanny ability to perceive the world in three dimensions (3D), otherwise known as depth perception. The amazing thing about this ability to determine distances is that it depends only on a simple two-dimensional (2D) image in the...
Freshwater zooplankton; Global warming; Nitrogen--Environmental aspects
Aquatic ecosystems face major transformations as humans increasingly alter their environment by introducing exotic species and changing the temperature regime and nutrient availability of freshwater systems. The impacts of such alterations of...
"One of Dali's most Freudian paintings. Indeed, the elderly gentleman helping the lady in distress seems to be Freud himself, borrowed from [Max] Ernst's Pietà or Revolution by Night." (Caption); "Illumined Pleasures is one Dali's...
Long train on a set of railroad tracks curving to the right around a steep mountain on the left with a drop-off to the right. Title: 8075- Rounding the Curves on Marshall Pass, Colorado, U.S.A. Text on left: Keystone View Company. Copyright 1898,...
Flowering royal poinciana tree with other multi-colored flowers. There is a building near the tree. Text printed on verso reads, "Florida is indeed the favored child of Nature. Beauty has been bestowed with lavish hand on this enchanted State...
