This thesis is divided into two parts below. Part I Adriamycin (ADR) can produce nephrotoxicity in rodents. The underlying mechanism may relate to ADR induced oxidative stress. In this study, we used transgenic mice (NMT3), which over-expressed the...
Because of limitations in randomized controlled trials, medical researchers are often forced to rely upon studies of observational data. Confounding is a major difficulty encountered in such studies that can create considerable bias in estimates of...
Pancreatic islet transplantation is a very promising treatment for type I diabetes. Many clinical trials have failed due to early islet loss and immune rejection. Reactive oxygen species (ROS) have been demonstrated to be involved in graft damage...
In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
The purpose of this dissertation is to find ways to decrease Medicare costs and to study health outcomes of diabetes patients as well as to investigate the influence of Medicare, part D since its introduction in 2006 using the CMS CCW (Chronic...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
The focus of this dissertation work is the formulation and improvement of anemia management process involving trial-and-error. A two-stage method is adopted toward this objective. Given a medical treatment process, a discrete Markov representation...
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
Much work has been done in the past on the nutritional value in young life of different dairy products, all of which experiments have been carried to successful completion by various men at different times. There is, however, no published...
The most important non-protein nitrogenous constituents of milk are urea, creatinine, creatine, and uric acid. Urea is the diamide of carbonic acid and is the chief end-product, so far as nitrogen is concerned, of the physiological metabolism of...
Buildings; University of Louisville--Buildings; Health care facilities;
Location: 615 South Preston Street. Current uses: Division of Nephrology of the Department of Medicine is housed in this building. Nephrology clinics and a dialysis unit provide treatment to patients with renal diseases, hypertension, and...
Frontier Nursing Service, Inc.; Nurses; Families; Newspapers; People
A nurse from the Frontier Nursing Service sits on a chair next to a mother holding an infant. The nurse wears a cap, long-sleeved blouse with a tie, pants, and an apron. The mother wears a v-neck sweater and a skirt and a bandana on her head....
Buildings; University of Louisville--Buildings; Parking garages; Automobiles;
Chestnut Street Parking Garage seen diagonally from the intersection with Preston Street. There is a woman crossing Chestnut Street and several cars are in the street, as well. The Kidney Disease Building stands next to the parking lot. Current...
