Alcoholic liver disease (ALD) ranks among the major causes of morbidity and mortality in the world and effects millions of patients each year. Progression of ALD is well characterized and is actually a spectrum of liver diseases, which progresses...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Diabetic cardiomyopathy (DCM) is a common complication leading to accelerated cardiovascular failure in diabetic patients. Even though the exact mechanism(s) behind this disease still remain unclear, research from several laboratories including our...
Schiller, Friedrich, 1759-1805. Über die ästhetische Erziehung des Menschen in einer Reihe von Briefen; Schiller, Friedrich, 1759-1805--Philosophy; Play (Philosophy)
Friedrich Schiller's psychological theory of play, his hypothesis about human nature, is embedded in the Aesthetic Letters . Its trans-historical value owes much to the committed interest in life in the late Enlightenment, and the theory itself is...
Several technical and economic obstacles currently hamper the industrial development of ethanol from biomass. One of the key bottlenecks is the slow kinetics of the enzymatic hydrolysis of cellulose, and the subsequent rate reduction as the...
Coal-fired power plants--Environmental aspects--United States; Mercury wastes--Environmental aspects--United States
This dissertation tests whether or not mercury emissions from electric power plants are not a significant contributor to mercury measurements in rainfall and argues that the current United States (U.S.) Environmental Protection Agency (EPA)...
Recently our lab has shown that with broadband stimuli (either visual noise or natural scenes), performance for detecting oriented content is worst at horizontal, best at the obliques, and intermediate at vertical orientations--an anisotropy...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Corpus callosum; Diagnostic imaging; Autism--Diagnosis
Early detection of human disease in today’s society can have an enormous impact
on the severity of the disease that is manifested. Disease such as Autism and Dyslexia,
which have no current cure or proven mechanism as to how they develop, can...
The Y family of DNA polymerases in higher eukaryotes contains at least four members which are implicated in potentially error-prone replication through unrepaired damage in the genome. These proteins are encoded by the REV1, POLH, POLI, and POLK...
Persons living with chronic pain encounter a host of physical and psychosocial problems resulting in a loss of quality of life and increased disability. The construct of avoidance has been proposed as a mechanism by which these changes in...
This thesis is divided into two parts below. Part I Adriamycin (ADR) can produce nephrotoxicity in rodents. The underlying mechanism may relate to ADR induced oxidative stress. In this study, we used transgenic mice (NMT3), which over-expressed the...
Background: Helicobacter pylori (Hp) establishes life-long gastric infection in billions of humans, and is often responsible for diseases such as peptic ulcer and gastric cancer. Cumulative actions of genetic drift and natural selection over...
Healthy Hoops Kentucky; Asthma in children--Social aspects; Asthmatics--Social conditions
Asthma is the most common chronic disease among children aged 7 to 17 years of age in the United States. An average, one of every ten school-aged children has asthma, and 13 million school days are missed each year due to asthma. Interventions to...
The thesis focuses on improving the flowrate of the Knudsen gas pump. The Knudsen pump uses thermal transpiration as the driving mechanism to pump gas. It is a motionless gas pump as the pump does not require any moving actuators for pumping. The...
Xenoestrogens are spread throughout the environment affecting our daily
lives and may produce potential toxic effects on human health. The purpose of
this study was to develop a mechanistically reliable model capable of identifying
xenoestrogens....
Farmers' markets--Kentucky--Louisville; African Americans--Nutrition; African American consumers--Kentucky--Louisville; Health promotion--Kentucky--Louisville--Citizen participation; Food--Social aspects
The purpose of this study is to obtain a better understanding of the interactions and the
social environment of the local farmers' markets, Fresh Stops, and Healthy in a Hurry
Corner Stores in West Louisville and East Downtown. This study will...
