Legal and illegal gambling opportunities are readily available to students on college campuses and surrounding areas (Saum, 1999). College students are at an age that is highly impressionable, experimental, and prime to taking risks while ignoring...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of...
The acetogenin annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina tri/oba...
The fundamental question of the exact nature of the role played by TNF in the failing myocardium remains one of contention. Many preclinical studies have demonstrated beneficial effects with TNF antagonism and recently the dichotomous role played...
Anxiety in children; Anxiety--Physiological aspects
Anxiety disorders are prevalent in both adult and child populations, and are associated with significant economic and psychosocial costs. There are clearly familial patterns of transmission within the anxiety disorders, and the inherited risk is...
The chaperone heat shock protein 90 (Hsp90) regulates physiologically and
pathological cellular processes, by binding and stabilizing kinases involved in basal
cellular functions and in cellular responses to stress, respectively. I hypothesize...
Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
Dialectical behavior therapy; Women prisoners--Rehabilitation; Women prisoners--Psychology; Women prisoners--Mental health services; Women prisoners--Mental health
This dissertation examines the effectiveness of a partial skills group component of Dialectical Behavior Therapy (DBT) in female prison inmates. DBT is an evidence-based comprehensive treatment which addresses emotional reactivity, impulsivity and...
Integrins are major receptors for cell adhesion to the extracellular matrix, and play key roles in various cellular processes including adhesion, migration, proliferation and survival. Apart from developmental and physiological events, integrins...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
