In blood coagulation, the serine protease thrombin is a multifaceted enzyme that interacts with multiple proteins. Thrombin utilizes two anion binding exosites (ABE-I and II) to supplement binding to fibrinogen and to the platelet receptor GpIbα,...
BACKGROUND: Regulated secretion of protein by salivary and other exocrine glands requires correct trafficking of soluble cargo proteins into secretory vesicles. However, the molecular mechanism of sorting in the parotid salivary gland is unknown....
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most fatal, with a rising incidence in the US as a result of the increase in alcoholic liver disease and obesity. Current therapeutic strategies are...
