Premenopausal women have fewer and less severe strokes when compared to postmenopausal females and aged matched males. The most obvious factor that could account for the observed difference is the physiological activity of Estrogen. Numerous...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Osteoporosis has become a growing health threat with rising social and economic consequences. The understanding of the relationship between bone mechanical strength and bone structural quality is important for the diagnosis of osteoporosis and the...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
Spinal cord--Wounds and injuries--Treatment; Physical therapy
Activity-based rehabilitation in the form of overground or body weight-supported treadmill (BWST) locomotor step training has become the most widely accepted therapy translated from preclinical animal research to spinal cord injury (SCI) patients....
Drug delivery systems; Curcumin--Therapeutic use--Administration
Curcumin, a plant derived compound has shown significant potency against various chronic diseases like cancer in cell culture and animal studies. However, the introduction of this compound into clinical setting is limited by its poor oral...
Spinal cord--Wounds and injuries; Stretch (Physiology)
An increasing amount of healthcare resources is used for the treatment and prevention of contractures in patients with spinal cord injury (SCI), with stretch and passive movements remaining the most prominent intervention methods. The results of...
Green tea--Health aspects; Green tea--Therapeutic use; Polyphenols--Physiological effect; Drug delivery systems; Lungs--Cancer--Treatment
Green tea polyphenols (GTPs) are gaining increasing attention because of their potential anti-tumor effects. However, poor oral bioavailability limits their efficacy in vivo. In this dissertation, two hypotheses were tested: 1) GTPs administered...
Much work has been done in the past on the nutritional value in young life of different dairy products, all of which experiments have been carried to successful completion by various men at different times. There is, however, no published...
Condensed milk--Research; Milk--Research; Dried milk--Research; Milk as food
Although much work has been done in determining the nutritional values of different milks, all of it has been carried on at different times by various men, and there is no published data demonstrating the relative values derived from experiments...
Naja kaouthia is a significant species because it feeds primarily on agricultural pests, causes human mortality, and is commercially exploited. Understanding the life history and demography of harvested populations is essential to providing...
The mechanisms by which estrogens regulate mitochondrial activity are not completely understood. Chronic treatment of ovariectomized rats with estradiol (E 2 ) increased the amount of Nuclear Respiratory Factor-1 (NRF-1) protein in cerebral blood...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
In the bulk of experiments on animal feeding the Albino Rat has served as the experimental animal. It has been proved that any diet which brings about satisfactory growth in white rats will also cause a young child to grow satisfactorily....
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
Walkways; Pied Piper of Hamelin (Legendary character); Women; Reading; Children; Play (Recreation); Castaways; Measuring; Men; Animals
Woodblock prints of, clockwise starting from top left: people strolling on path through tall palm trees; Pied Piper causing rats to jump into water, and leading children into cave; old woman napping in chair with book in her lap; children playing...
