Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Leopold, Aldo, 1886-1948; Naturalists--United States--Biography; Wildlife conservation--Study and teaching (Higher); Ecology--Study and teaching (Higher)
This historic case study addressed the issue of the lack of citizen action toward environmentally responsible behavior. Although there have been studies regarding components of environmental responsible behavior [ERB], there has been little focus...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
We are more likely to "hurt the one's we love" than we are complete strangers (cf. R. Miller, 1991, 1997). Early in dating relationships, partners appear to me more likely to manage their impressions to present themselves as better than...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
St. Irene (Church : Istanbul, Turkey); Irene, Empress of the East, 752?-803; Constantine V Copronymus, Emperor of the East, 718-775; Apses (Architecture)--Turkey--Istanbul; Art patronage--Turkey--Istanbul--History--8th century
The mosaic of the cross in the apse of Hagia Eirene in Constantinople is examined in order to determine the imperial patron responsible for it's construction. Key points in this study are Orthodox image veneration, Iconoclast doctrine and the...
Cardiac mapping has become an important area of research for understanding the mechanisms responsible for cardiac arrhythmias and the associated diseases. Current technologies for measuring electrical potentials on the surface of the heart are...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
Background: Helicobacter pylori (Hp) establishes life-long gastric infection in billions of humans, and is often responsible for diseases such as peptic ulcer and gastric cancer. Cumulative actions of genetic drift and natural selection over...
Ischemic heart disease is the leading cause of mortality and morbidity in Western societies. Thus, understanding the molecular mechanisms to reduce myocardial ischemia and limit infarction size are of great importance. Ample evidence has shown that...
Income distribution; Occupational training--Economic aspects; Academic achievement--Economic aspects
Employing a two-stage least-squares multiple regression technique using cross-sectional data from metropolitan statistical areas (MSAs) as the unit of analysis, this study is designed to detect the indirect effect of skill-biased technological...
Visual learning; Animated films--Japan; Motion pictures in education; Audio-visual education
Our contemporary culture is laden with a glut of visual stimuli: advertising, packaging, television, film, the internet, digital-camera-wireless-web-access-mobile-phones. In a world filled with visually rhetorical media, it is imperative that the...
The lipid aldehydes, 4-hydroxy-2-nonenal (4-HNE) and propene-2-al (acrolein) are reactive α,β-unsaturated aldehydes generated during the peroxidation of lipids and are implicated in the pathogenesis of several oxidative-stress mediated diseases,...
This thesis deals with the events and issues which were connected with the 1935 gubernatorial election. There is first a brief sketch of Kentucky politics prior to the 1935 election. Particular interest is given to the history of the Democratic...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
