Epithelial Ovarian cancer (EOC) is the leading cause of gynecological cancer death in the USA. Recurrence rates are high after front-line platinum chemotherapy and most patients eventually die from platinum-resistant disease. P53 plays an important...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
This study examined two questions related to interpersonal change as an outcome of Time-Limited Interpersonal Therapy (TLIPT). The first asked if clients experience both symptom change and interpersonal change when treated with TLIPT. The second...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Aims. The primary aim of this randomized, blinded, controlled clinical trial was to compare the percent root coverage obtained using acellular dermal matrix allograft and connective tissue graft using the coronally positioned tunnel technique 4...
Aims. The primary aim of this randomized, blinded, controlled clinical trial was to compare the percent root coverage obtained using a coronally positioned tunnel surgery plus an acellular dermal matrix allograft (ADM) with single tooth sling...
Chronic periodontitis is strongly associated with composition of the oral biofilm
occupying the gingival crevicular aspect of the tooth and its associated root. Some gram-negative,
"red complex" bacteria instigate periodontal bone loss in...
Menthol has been regularly utilized as a treatment in sports related injuries for many years, yet little is known about its physiological interactions or its effect on performance. Our previous study indicates that topically applied menthol may...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
Within the discipline of rhetoric and composition, the notion of coherence possesses the status of sine qua non, yet this notion has been treated unevenly or been taken for granted, much as the process of composing itself was taken for granted for...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
I will report the development of a semi-empirical self-consistent and environment-dependent model Hamiltonian, which is intended to treat large systems in the order of 10000 atoms. This covers a range of important physical phenomena that are too...
Background: For more than 10 years, Invisalign has been a treatment alternative to traditional bands and brackets for the treatment of malocclusion. In order to relieve crowding in the dentition, interproximal reduction (IPR) or stripping is often...
Pancreatic islet transplantation is a very promising treatment for type I diabetes. Many clinical trials have failed due to early islet loss and immune rejection. Reactive oxygen species (ROS) have been demonstrated to be involved in graft damage...
Aims . The primary aim of this study is to compare the clinical and histologic results of a flap vs. a flapless technique of ridge preservation after 4 months of healing. Both groups received an intrasocket graft of demineralized bone matrix mixed...
Reperfusion of the ischemic lung causes pulmonary arteriolar vasoconstriction and reduces alveolar perfusion. Lung ischemia-reperfusion (IR) injury leads to platelet and leukocyte activation which could contribute to decreased alveolar perfusion...
Wounds and injuries--Treatment; Drug delivery systems
Wounds care and management is one of the most basic needs in the medical setting. Burn wounds, trauma wounds, pressure ulcers and bedsores are just some of the many types of wounds that need to be treated quickly and efficiently. Take for instance...
Background and significance: Even with the advent of direct bonding, decalcification remains a problem in orthodontics today. Glass ionomer cements have been used in dentistry for fluoride release for years and may have beneficial use in...
The purpose of this research project is to evaluate the feasibility of interhospital patient transfers (within a hospital corporation referred to as NESW Hospital Co.) as a means of reducing emergency department overcrowding. Customer satisfaction...
