Influenza--United States--Management; Epidemics--Management; Health services administration; Mathematical optimization
Pandemic influenza has been an important public health concern. During the 20th century, three major pandemics of influenza occurred in 1918, 1957, and 1968. The pandemic of 1918 caused 40 to 50 million deaths worldwide and more than 500,000 deaths...
Chapter I . Seven novel head-to-tail cyclic pentapeptides and pseudopentapeptides containing the arginine-glycine-aspartic acid (RGD) tripeptide motif were synthesized. All of the peptides were constructed using solid phase peptide synthesis....
Vicinal dithioethers and alkenyl thioethers were synthesized under environmentally
friendly conditions using alkyne and thiol in water. Alkynes were also used to develop a
multibond-fonning reaction that fonned cyclic ketones or ketoesters through...
Our research activities are based on the catalytic systems that provide resource-saving synthetic methodologies through gold-catalyzed reactions of alkynes and alkenes. We have worked on three applications: i) an effective and straightforward...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. A quarter of the first two pages of this issue is missing as well as significant other portions. The following six pages...
It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
In the present study, we report the synthesis of thermally stable mesoporous gallium oxide and novel gallium-niobium mixed oxides employing Evaporation Induced Self-Assembly (EISA), Self-Assembly Hydrothermal-Assisted (SAHA) and Self-Assembly...
Parkinson's disease--Treatment; Stem cells--Therapeutic use
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the
progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and
the resulting imbalance between dopamine and acetylcholine in the basal ganglia...
Soon after the atomic theory was established, it was found that the plant uses as sources of food not only the air and water, but also different constituents of the soil, dissolved in the soil moisture—the mineral nutrients. Ashes of different...
University of Louisville. Medical Dept.; Medical students; Teachers
University of Louisville medical department 1911 - Composite photograph for the University of Louisville school of medicine in Louisville, Kentucky, of faculty and graduating students for the medical school class of 1911. Individual oval-shaped...
This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...
The Y family of DNA polymerases in higher eukaryotes contains at least four members which are implicated in potentially error-prone replication through unrepaired damage in the genome. These proteins are encoded by the REV1, POLH, POLI, and POLK...
Louisville Medical College; Medical students; Teachers
Louisville Medical College 1893 - 1894. Composite photograph for the Louisville Medical College in Louisville, Kentucky, of faculty and graduating students for the medical school class of 1893-1894. Oval-shaped cluster of individual oval-shaped...
Hematite synthesized by low pressure oxygen plasma has been shown previously to exhibit promising characteristics as a photo-anode for a photoelectrochemical water splitting cell. It is cheap, stable and has a 2.1 eV bandgap and exhibits a...
Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...
The oxidation of metallothiolates is complicated by "non-innocence" or potential
redox activity of sulfur to yield thiyl (RS•) radicals. In some instances, the one-electron
oxidation of metal thiolates yields a product with the unpaired...
This thesis describes 1) the kinetics of vapor phase place exchange reactions on films of gold monolayer protected clusters (Au MPCs) to alter the functionality of the Au MPCs, 2) applications of the reaction for altering chemiresistive sensing...
Protein C (PC) is an important anticoagulant, antithrombotic, and antiinflammatory in blood plasma. PC deficiency can lead to severe venous thrombotic events, including lung embolism, stroke, and heart attack. In the body, PC is activated only when...
Arrhythmia; Heart--Diseases; Heart beat; Heart conduction system
Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death...
Conducting polymers; Polymers in medicine; Myocardium
Hydrophilic and conductive characteristics in polymers are mutually exclusive of each other. Hydrophilic polymer properties allow absorption of water up to several magnitudes above their dry weight. However, due to their molecular structure, they...
