Parkinson's disease--Treatment; Stem cells--Therapeutic use
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the
progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and
the resulting imbalance between dopamine and acetylcholine in the basal ganglia...
Theaters--Kentucky--Louisville; Louisville (Ky.)--Buildings, structures, etc.
A child is considered by some psychologists to pass through on its way to manhood the stages through which the race has passed on its way to civilization. If this is true of a single man, might it not equally be true of a community of men? Have not...
A new procedure has been developed for determining
the location of the source of certain EEG discharges
given the measured surface potentials. The
source is modeled as a single current dipole with arbitrary
position and orientation, while the head...
This study of Mably’s works was undertaken because of the scant treatment thus far accorded the writings of a philosopher, important in his own century, and peculiarly interesting today in view of the present partial realization of many of his...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Protein C (PC) is an important anticoagulant, antithrombotic, and antiinflammatory in blood plasma. PC deficiency can lead to severe venous thrombotic events, including lung embolism, stroke, and heart attack. In the body, PC is activated only when...
Night vision--Genetic aspects; Vision disorders--Genetic aspects
Mutations in the NYX gene, encoding the novel protein nyctalopin, cause human congenital stationary night blindness type 1 (CSNB1). CSNB1 is an X-linked recessive condition and is identified by a loss of the electroretinogram (ERG) b-wave while the...
The use of a fluidized bed dryer to dry acrylo-nitrile-
butadiene-styrene terpolymer was studied. Data for
fluidized bed drying were obtained from the Monsanto
Company's fluid bed dryer. Fluid bed theory, drying
phenomena, and fluid bed drying...
Drug resistance in microorganisms--Mathematical models; Intensive care units
Antibiotic resistance is a problem causing growing concern in the medical community, leading some to speculate that a return to the preantibiotic era is imminent. The problem of antibiotic resistance is particularly significant in the intensive...
After a careful study of Madison Cawein's poetry, and comparing his views on religion and philosophy with those of some of the great English poets, Wordsworth, Shelley, Byron, Tennyson and Browning, I shall summarize them as follows, and treat each...
Congenital stationary night blindness 1 (CSNBl) is a genetic disorder characterized in humans by night blindness, low visual acuity and myopia. CSNB 1 is caused by defects in genes that are involved in signaling between photoreceptors and...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
Guthrie, James, 1792-1869; Kentucky--Officials and employees; Kentucky--Politics and government--19th century
James Guthrie, like any man, may be considered as a private individual, as a participant in the economic activities of his time, and as a citizen. Of Guthrie’s personal life little is known besides the barest biographical outline. His business...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Phase II clinical trial are generally single arm trial where a homogeneity assumption is placed on the response. In practice, this assumption may be violated resulting in a heterogeneous response. This heterogeneous or overdispersed response can be...
When observers view a naturalistic (l/f) broadband image, the various spatial components present in the image stimulate many detecting-mechanisms that suppress each other. This suppression is anisotropic, being relatively greater for mechanisms...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
Football--United States; College sports--United States; Sports spectators--United States--Attitudes; Sports spectators--United States--Psychology; Consumer behavior--United States
Recently, some college football programs have experienced unsustainable attendance growth, increases in revenue discrepancies, stagnant "revenue growth", and increased operating costs (Brown, 2009; Fulks, 2009; Fullerton & Morgan,...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Periodontal disease arises from excessive host inflammatory responses to the tooth-associated microbial biofilm, known as dental plaque. Severity ranges from superficial inflammation of the gingivae (gingivitis) to extensive destruction of...
