T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death...
Sensor networks are just in their infancy. Their use will continue to grow as the technology becomes cheaper and more efficient. A current shortcoming with sensor networks is the inability to efficiently provide secure communications. As sensor...
INTRODUCTION: Heart failure is a major and growing public health concern. Although heart failure has been considered an inexorable and progressive disorder, emerging evidence suggests that some patients may have reversible left ventricular...
Given a metric space (K, d), the hyperspace of K is defined by H(K) = {F c K: F is compact, F ≠ 0}. H(K) is itself a metric space under the Hausdorff metric dH. Hyperspaces have been extensively studied by topologists since the 1970's, but the...
Molybdenum-sulfur complexes have developed a lot of interest in the chemistry of metal-coordinated sulfur due to their importance in biological systems and in industrial processes like catalysis. For example, in biological processes molybdenum has...
This dissertation deals with various imidazole compounds with emphasis on hydrogen bond interactions and weaker intermolecular forces. New amide functionalized polyimidazole metal binding pockets are able to form intramolecular six-membered...
Clustered longitudinal data is often collected as repeated measurements on subjects over time arising in the clusters. Examples include longitudinal community intervention studies, or family studies with repeated measures on each member. Meanwhile,...
This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and...
Outerplanar graphs are planar graphs that have a plane embedding in which each vertex lies on the boundary of the exterior region. An outerplanar graph is maximal outerplanar if the graph obtained by adding an edge is not outerplanar. Maximal...
Online organizations are always in search for innovative marketing strategies to better satisfy their current website users and lure new ones. Thus, recently, many organizations have started to retain all transactions taking place on their website,...
Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Despite the development of various strategies to treat cancer, it remains one of the most deadly diseases worldwide due to the limited effects...
Acrolein--Toxicology; Stem cells--Effect of pollution on
Acrolein is a common pollutant present in ambient air, automobile exhaust, and tobacco smoke. Previous studies show that exposure to acrolein increases cardiovascular disease risk. To determine whether acrolein affect cardiovascular regeneration,...
Chapter I . Seven novel head-to-tail cyclic pentapeptides and pseudopentapeptides containing the arginine-glycine-aspartic acid (RGD) tripeptide motif were synthesized. All of the peptides were constructed using solid phase peptide synthesis....
The acetogenin annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina tri/oba...
Periodontitis--Treatment; Peptides--Therapeutic use
Periodontitis and its systemic sequelae remain a major public health problem and
developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of
Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization of the...
For complex classification systems, data is usually gathered from multiple sources of information that have varying degree of reliability. In fact, assuming that the different sources have the same relevance in describing all the data might lead to...
Myocardial infarction; Glucose--Metabolism; Mitochondrial DNA
Heart failure is a leading cause of morbidity and mortality in the USA. During the development of heart failure, many cardiac parameters change at the same time including fuel metabolism, oxidative stress and mitochondrial function. Each of these...
The revolution in information technology and the explosion in the use of computing devices in people's everyday activities has forever changed the perspective of the data mining and machine learning fields. The enormous amounts of easily...
