Long-term exposure to harmful carcinogens like benzo[a]pyrene (BaP) are linked to lung cancer. Benzo[a]pyrene diol epoxide (BPDE), the ultimate carcinogen produced by BaP bioactivation, is believed to play an important role in lung carcinogenesis....
Epithelial Ovarian cancer (EOC) is the leading cause of gynecological cancer death in the USA. Recurrence rates are high after front-line platinum chemotherapy and most patients eventually die from platinum-resistant disease. P53 plays an important...
Homeless persons--Services for--Kentucky--Louisville; Homelessness--Kentucky--Louisville; Inmates of institutions; Community-based social services--Kentucky--Louisville
The purpose of this study was to examine the link between various aspects of service utilization and the institutionalization of homeless individuals. The researcher wished to determine whether participation in various therapeutic, medical, and...
Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged...
c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...
Birth control--United States--History--20th century
This thesis is an examination of the tactics used by individuals in the development of the twentieth century birth control movement. It focuses on the creation of a national organization that directed the movement throughout the United States. The...
Dimorphism is a highly conserved process in fungi in which a transition between a unicellular, yeast-like growth form and either a unicellular or multicellular, filamentous growth form occurs in response to several different environmental cues. The...
Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
United States. Army--History; Federal aid to law enforcement agencies--United States; Riots--United States
The function of the army of the United States is to protect the country against all enemies foreign and domestic. Everyone is cognizant of the accomplishments of the American forces against its foreign enemies; but there is another work, of equal...
Discrimination in criminal justice administration--United States; Drug control--Social aspects--United States; War on Terrorism, 2001- --Social aspects; Crime and race--United States; United States--Race relations
This thesis is an examination of the relationship between race and ethnicity and the American justice system. It is a comparative case study of the racial dimensions of the War on Drugs in the domestic criminal justice system and the ethnic...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Executions and executioners--Press coverage; Mass media and public opinion; Capital punishment in popular culture; Death row inmates--Press coverage
The public's exposure to state sanctioned killings is limited to the mass media representations such as editorials, news reports, feature films, and books. Therefore it is important to examine the process of execution and its relation to the media...
Human adenoviruses (Ads) can infect and replicate in cells at different cell-cycle stages. Ads with the E1 B55K deletion preferentially replicate in cancer cells and cause oncolysis. Our laboratory has previously shown that the Ad E1 b gene is...
Drugs and crime are inextricably connected. Much of the growth in the prisoner population in America is attributable to the misuse and abuse of drugs and alcohol. Offenders who abuse or are dependent on drugs are at high risk for substantial health...
Alternatives to imprisonment--Kentucky--Jefferson County; Juvenile corrections--Kentucky--Jefferson County
Since the beginning of the juvenile justice movement in the United States over a century ago, considerable debate has persisted among policymakers and practitioners concerning the causes of juvenile offending and the appropriate responses to...
The Y family of DNA polymerases in higher eukaryotes contains at least four members which are implicated in potentially error-prone replication through unrepaired damage in the genome. These proteins are encoded by the REV1, POLH, POLI, and POLK...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 31. No. 48. but is actually Vol. 31. No. 40. There is a tear across the center of each page that...
Due to of the rise in numbers of persons experiencing homelessness, communities are working to restrict access that homeless individuals have to public spaces. Many cities across the nation have criminalized aspects of homelessness in attempts to...
