Persecution--England--History--16th century; Martyrdom--Christianity--England; Great Britain--History--Elizabeth, 1558-1603; Great Britain--History--Mary, 1553-1558
This thesis is a historical examination of the Marian and Elizabethan persecutions. Through the analysis of primary sources dating from the persecutions, the process of persecution in Reformation England is examined. This thesis uncovers the...
Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast,...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Oxidative stress-induced immunosuppression could be due to a decrease in CD4 + T lymphocyte activation or proliferation. 4-Hydroxynonenal (HNE), an end product of lipid peroxidation, and its protein adducts act as markers of oxidative stress. In...
Middle school education--Case studies; Academic achievement--Kentucky; Home and school--Kentucky
This dissertation is a case study of 109 students and their parents from a small rural, middle school community in Western Kentucky. It seeks to determine the interrelationships between conservative Protestant Parent Values (Parent Rural Values and...
Reformation--England; Henry VIII, King of England, 1491-1547; Monasticism and religious orders--England--History
This thesis is a critical examination of the dissolution of the monasteries under the reign of Henry VIII, and the key role the dissolution played in his plan for the Reformation in England. In addition, the present study found that by closely...
This thesis deals with the events and issues which were connected with the 1935 gubernatorial election. There is first a brief sketch of Kentucky politics prior to the 1935 election. Particular interest is given to the history of the Democratic...
T lymphopoiesis has been an intense focus of immunological research since the discovery of the major histocompatibility complex (MHC) and T cell mediated transplant rejection. Additionally, researchers have long appreciated the role of T cells, and...
Pancreatic beta cells are extremely vulnerable to destruction by Reactive Oxygen Species (ROS). In type 1 diabetes and islet transplantation ROS are thought to be involved in the loss of beta cells. To test the role of antioxidant in islet...
The vaccinia virus complement control protein (VCP) is involved in the modulation of the host inflammatory response during vaccinia virus infection. It possesses the ability to inhibit both classical and alternative pathways of complement...
Women--Kentucky--Louisville; Social reformers--Kentucky--Louisville--History; Morel, Louise C., b. 1871
Louise C. Morel was a leading social reformer in Louisville from 1917 through the early 1940s. Morel's work is a primary example of the continuation of Progressive Era ideals into the decades after the traditional end of the Progressive Era....
Kentucky--Governor (1859-1862 : Magoffin); Kentucky--History--Civil War, 1861-1865; United States--History--Civil War, 1861-1865
This thesis seeks to understand Beriah Magoffin as Governor of Kentucky. Adding to the work begun by Michael T. Dues and Lowell H. Harrison during the 1960s and 1970s, this thesis fleshes out a man little studied in history. It addresses several...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Pancreatic beta cells are extremely vulnerable to the destruction of Reactive Oxygen Species (ROS). In both type 1 and type 2 diabetes ROS are involved in the loss of U+000DF-cells. We hypothesized that the deficiency in ROS detoxifying system of...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
Kennedy, John F. (John Fitzgerald), 1917-1963; Nkrumah, Kwame, 1909-1972; United States--Foreign relations--Ghana; Ghana--Foreign relations--United States; Volta River (Ghana)
The emergence of an independent neutralist Africa changed the dynamics of the cold war. The military-strategic orientation of the United States and Soviet Union had little relevance to underdeveloped Africa. Following the death of Joseph Stalin,...
The ability of L. pneumophila to cause disease depends on its replication in alveolar macrophages. Infectivity and the expression of various virulence traits is triggered at post exponential growth phase. We show that unlike quiescent macrophages,...
Pro-life movement--United States--Case studies; Rhetoric--United States; Abortion--United States
The purpose of this study is to consider the significance of rhetoric used by pro-life social movement organizations to frame the experience of abortion and to label those women who have participated in that experience. The study explores how...
