Polymorphisms in the adrenergic receptor beta-2 (ADRB2) gene have been studied in relation to risk of Type 2 diabetes and obesity, but few studies have investigated associations with breast cancer. The purpose of this research was to evaluate the...
Nonparametric statistics; Estimation theory; Distribution (Probability theory)
Multistate models are a type of multi-variate survival data which provide a framework for describing a complex system where individuals transition through a series of distinct states. This research focuses on nonparametric inference for general...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
Urinary incontinence is a major public health problem affecting 30% of community dwelling women aged 35-85. Urinary incontinence may have a significant impact on activities of daily living depending on the severity of symptoms. Women with urinary...
Infants--Wounds and injuries; Falls (Accidents); Neck--Wounds and injuries; Head--Wounds and injuries
The purpose of this study was to determine the risk of severe head and neck injury in short distance falls for a 12-month-old child. A series of free falls and falls from standing were experimentally simulated using an instrumented anthropomorphic...
The phase II clinical trial is a critical step in the drug development process. In the oncology setting, phase II studies typically evaluate one primary endpoint, which is efficacy. In practice, a binary measurement representing the response to the...
Clustered longitudinal data is often collected as repeated measurements on subjects over time arising in the clusters. Examples include longitudinal community intervention studies, or family studies with repeated measures on each member. Meanwhile,...
Tallis, Thomas, ca. 1505-1585. Lamentations, no. 1; Tallis, Thomas, ca. 1505-1585. Lamentations, no. 2; Byrd, William, 1542 or 3-1623. De Lamentatione Hieremiae;
Movement through pitch space in the Common Practice Period is generally acknowledged as being structured on the fifth relation, whereas movement through the pitch space of the highly chromatic music of the nineteenth century is thought of as being...
Dynamic analysis and parameter identification of a single mass elastomeric isolation system represented by Maxwell model is examined using both analytical and experimental approaches in this dissertation. Influences that the stiffness and damping...
Vicinal dithioethers and alkenyl thioethers were synthesized under environmentally
friendly conditions using alkyne and thiol in water. Alkynes were also used to develop a
multibond-fonning reaction that fonned cyclic ketones or ketoesters through...
Prostate cancer (PCA) development may be influenced by genetic variations within oxidative stress response (OSR) related mechanisms, such as antioxidation (e.g.,
carcinogen metabolism/detoxification), DNA repair, and apoptotic regulation. Excessive...
Ten algal isolates were obtained from soil into axenic culture and placed into defined media containing from 0 to 50 ppm of DDT, 2, 4-D,2,4,5-T, rotenone, or malathion (in two purities, 95 and 99%). For nine of the isolates, growth was measured...
Marginal inference for waiting times in multi-stage time-to-event models is complicated by right censoring of observations as well as the prior history of events in the model. In general, complications arise due to the evolution of the censoring...
In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both...
Because of limitations in randomized controlled trials, medical researchers are often forced to rely upon studies of observational data. Confounding is a major difficulty encountered in such studies that can create considerable bias in estimates of...
Faroe Islands; Human beings--Migrations; Human geography--Faroe Islands
The Faroe Islands are a small archipelago in the North Atlantic. With a current population of approximately 49,000 individuals and evidence of high levels of genetic drift, the Faroese are thought to have remained highly homogeneous since their...
This study expands our efforts to make a new class of Pt (II) compounds analogous to cisplatin and its derivatives using sterically hindered ligands. Pt compounds in this series have been synthesized using specially designed pyridine and...
Medical appointments and schedules; Simulation methods
Healthy for Life is a relatively new University of Louisville medical clinic which attempts to stem the epidemic of childhood obesity. This program offers a range of face-to-face services for overweight children. The main problem addressed by this...
Hypertension--Genetic aspects; Coronary heart disease--Genetic aspects; African Americans--Health and hygiene
Cardiovascular diseases, including hypertension, are the leading causes of death in
the United States. African-Americans carry the highest burden of disease with 32% of
adults with hypertension. Blood pressure (BP) dipping, defined as a drop of>...
Pattern perception--Data processing; Pattern recognition systems; Land mines--Detection; Data mining
For complex detection and classification problems, involving data with large intra-class variations and noisy inputs, no single source of information can provide a satisfactory solution. As a result, combination of multiple classifiers is playing...
