Heart--Hypertrophy; Heart--Physiology; Sugar in the body; Metabolism; Diabetes--Research
Heart failure is recognized as a major cause of death among diabetics. In type I and II diabetes, glucose uptake, glycolysis and pyruvate oxidation are impaired, and fatty acid utilization increases. These alterations in metabolism contribute...
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
This quantitative dissertation examines risk assessment and recidivism of child maltreatment to determine the relationship between child protective services provided by the Kentucky Department of Protection and Permanency and risk of harm. A chart...
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
Integration of the Internet with a Cellular Network, WMAN, WLAN, and MANET presents an exceptional promise by having co-existence of conventional WWANs/WMANs/WLANs with wireless ad hoc networks to provide ubiquitous communication. We call such...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Diabetic cardiomyopathy (DCM) is a common complication leading to accelerated cardiovascular failure in diabetic patients. Even though the exact mechanism(s) behind this disease still remain unclear, research from several laboratories including our...
O -linked β-N-acetylglucosamine ( O -GlcNAc) is an inducible, dynamically cycling, and reversible post-translational modification of serine/threonine amino acid residues of nucleocytoplasmic and mitochondrial proteins. O -GlcNAc transferase (OGT)...
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of...
Critical thinking--Study and teaching (Higher); Critical thinking--Ability testing; Social work education
This study utilized the standardized California Critical Thinking Skills Test (CCTST) Form 2000 to measure students' pretest and post test critical thinking abilities prior to and upon completion of a critical thinking infused curriculum. In...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
A growing interest has manifested itself within the past two or three years in "phytin" and "phytic acid", and in some of the compounds of the latter. Posternak first isolated this substance from the seeds of the red fir,...
Guanine-rich oligonucleotides (GROs) are being developed as a novel anticancer agents. GROs exhibit potent antiproliferative properties against several malignant cell lines and in established in vivo tumor models. In a recent Phase I clinical trial...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 7. No. 38. but is actually Vol. 7. No. 41.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue celebrates the 20th anniversary of the Louisville Leader and is sixteen pages. The first page is very faded...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue is four pages and there is a crease across the center of page one that makes some lines illegible.
Congenital stationary night blindness 1 (CSNBl) is a genetic disorder characterized in humans by night blindness, low visual acuity and myopia. CSNB 1 is caused by defects in genes that are involved in signaling between photoreceptors and...
English literature--Early modern, 1500-1700; Geographical discoveries in literature
It is the purpose of this thesis to show what influence the sixteenth century voyagers had on the Elizabethan writers. For expediency, we have divided these voyages into two classes: namely, the early, from Columbus, 1492, to Vasca de Gama, 1498;...
Varnish and its use has been known since ancient times. Altho the knowledge of varnish has been attributed to the Japanese as early as 500-600 B.C., Tschirsch and A.D. Stevens say that the Japs did not possess this art originally, but that they...
