Guthrie, James, 1792-1869; Kentucky--Officials and employees; Kentucky--Politics and government--19th century
James Guthrie, like any man, may be considered as a private individual, as a participant in the economic activities of his time, and as a citizen. Of Guthrie’s personal life little is known besides the barest biographical outline. His business...
Inflammatory bowel disease (IBD) is a chronic autoimmune disorder that is subdivided into Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC). Epidemiological studies have proven that genetic variation increases...
Periodontitis is a chronic, destructive inflammatory disease of the supporting
tissues of the teeth with a high prevalence among adults. While the complete
pathogenesis of periodontitis remains unclear, it is initiated and sustained by...
Prostate--Cancer--Diagnosis; Chemical detectors; Biosensors
Prostate cancer is the most common type diagnosed among men in the United States.
Random oligodeoxynucleotide (ODN) libraries are used to generate DNA aptamers by
systematic evolution of ligands by exponential enrichment (SELEX). We explored...
Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. No. 29. but is actually Vol. 32. No. 32. There is a tear across the center of each page that has...
T cells; Disease susceptibility; Lupus; Sex factors in disease
Females are more susceptible to autoimmune disease than males. In several mouse models of disease, castration of males exacerbates disease while androgen treatment ameliorates disease. These data suggest hormones can have an influence on disease...
Complement, an early recognition system of innate immunity that senses local tissue damage and infection, cross-talks with and regulates other signaling systems, including Toll-like receptor (TLR) pathways. In the context of periodontitis,...
Church buildings--Spain; Church architecture--Spain; Spain--History--711-1516
This dissertation examines the architectural evidence in the ongoing debate surrounding the demographical and political value of the shifting Iberian frontier of the tenth through twelfth centuries. In particular, it seeks to problematize the...
Unrepaired DNA damage poses a serious threat to the genetic stability of a replicating cell. One mechanism of tolerating this damage is translesion DNA synthesis (TLS), in which an accessory polymerase synthesizes DNA directly across from a damaged...
Epithelial Ovarian cancer (EOC) is the leading cause of gynecological cancer death in the USA. Recurrence rates are high after front-line platinum chemotherapy and most patients eventually die from platinum-resistant disease. P53 plays an important...
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with free radicals, however, SFN works by inducing Nrf2, a transcription factor that binds to...
Clement VI, Pope, ca 1291-1352; Popes--Primacy--History; Popes--Temporal power--History
The papacy of Clement VI (1342-1352) was distinguished by
its political activism, its attempt to resurrect the impetus
for crusading, and its efforts to attract the best and
brightest talents to Avignon. The attributes which
characterize his...
G-quadruplexes are thought to have biological importance, with studies based on small molecule interactions and quadruplex-interactive antibodies demonstrating their potential for formation in vivo. One potential biological function of quadruplex...
Females have a higher incidence of autoimmune diseases than males for reasons that are currently unknown. CD4+CD25+ regulatory T cells play an important role in the maintenance of immunological homeostasis and self-tolerance by suppressing...
Medical education; Medical students; University of Louisville. Medical Dept.
Catalog for University of Louisville medical department 1867-1868. Includes a list of board of trustees and faculty, circular for 1867-1868, and catalog of the class for session 1866-1867 listing student names and residence. Printed on the cover:...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There is a significant portion missing down the center of each page of this issue and page one is very faded.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. An article has been clipped from pages five and six of this issue.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 15. No. 36. but is actually Vol. 15. No. 37. This issue is twelve pages. There are portions missing...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There is a tear down the center of each page of this issue.
