Oxygen is critical to aerobic metabolism, but hyperoxia is cytostatic and cytocidal. The precise mechanisms involved in hyperoxic cell injury remain incompletely understood although there is substantial support for the possibility that hyperoxia...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
In recent years, a number of computational and statistical problems for identifying SNP-SNP interactions in high dimensional survival data have been studied, and several data mining approaches have been proposed. However, the relative performance...
Naja kaouthia is a significant species because it feeds primarily on agricultural pests, causes human mortality, and is commercially exploited. Understanding the life history and demography of harvested populations is essential to providing...
A common research interest in medical, biological, and engineering research is determining whether certain independent variables are correlated with the survival or failure times. Standard statistical techniques cannot usually be applied for...
Municipal government--Japan--Case studies; Administrative agencies--Reorganization; Globalization--Political aspects; Globalization--Government policy; Globalization--Japan; Tokyo (Japan); Osaka (Japan)
This study examines the effects of globalization on state restructuring and the status of cities and local governments. I conduct a comparative case study of two Japanese world cities, Tokyo and Osaka, Japan. Existing globalization theories offer...
Data mining; Lungs--Cancer; Outcome assessment (Medical care)
Lung cancer is the leading cause of cancer death in the United States and the world, with more than 1.3 million deaths worldwide per year. However, because of a lack of effective tools to diagnose Lung Cancer, more than half of all cases are...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
In this dissertation research, we aim to solve problems of two types of survival data, clustered survival data with potentially informative cluster size and sojourn time data. The methods for these two types of data are different. However, both...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Problem children--Education--United States; Alternative schools--United States; School discipline--United States; Juvenile detention--United States; School children--United States--Discipline
Alternative school settings for students who are identified as "disruptive or dangerous" are playing an increasingly prominent role in the world of public education, yet many gaps in the research literature are abound. This dissertation...
Nontraditional college students--Kentucky--Louisville; English language--Rhetoric--Study and teaching (Higher); College freshmen--Kentucky--Louisville
This dissertation explores the role first-year composition (FYC) courses play in the academic lives of working-class adult students in the University of Louisville, an institution that, during portions of its long history, has been a valuable...
Because of limitations in randomized controlled trials, medical researchers are often forced to rely upon studies of observational data. Confounding is a major difficulty encountered in such studies that can create considerable bias in estimates of...
Legal and illegal gambling opportunities are readily available to students on college campuses and surrounding areas (Saum, 1999). College students are at an age that is highly impressionable, experimental, and prime to taking risks while ignoring...
Cortical and tectal inputs to the caudal LPN in the rat were examined using anatomical and physiological techniques. Pyramidal cells in layer 6 of the visual cortex and wide-field vertical cells in the stratum opticum of the superior colliculus...
Genes in folate metabolizing pathway are responsible for modulating key enzymes in folate metabolisms necessary for DNA synthesis and repair and influence DNA methylation. Irregularity in DNA methylation may modify tumor phenotype response to...
A process for fabricating PMOS transistors and test devices has been developed for educational purposes as part of a microfabrication undergraduate/graduate laboratory course at the University of Louisville. This is to help students from multiple...
This study investigated teachers' inclusion of racially diverse literature within their classroom libraries, how the representations within the literature compared with the students in the classrooms, the inclusivity of students' book selections,...
Marginal inference for waiting times in multi-stage time-to-event models is complicated by right censoring of observations as well as the prior history of events in the model. In general, complications arise due to the evolution of the censoring...
Algebra--Study and teaching (Secondary); Motivation in education; Feedback (Psychology)
The double-blind study used two intact ninth grade high school Algebra One classes for a total sample size of 46. Within each of the classes the participants were assigned randomly to one of three treatment groups: self-referenced feedback,...
