Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
Capital punishment--Public opinion; Murder victims' families--Attitudes; Murder victims' families--Psychology
Two common assumptions are that the family members of murder victims will achieve closure and perceive a sense of justice following the execution of their loved one's murderer. These assumptions, however, may be unfounded. Using family member...
The classification of self-dual codes has been an extremely active area in
coding theory since 1972 [33]. A particularly interesting class of self-dual codes
is those of Type II which have high minimum distance (called extremal or...
Given a metric space (K, d), the hyperspace of K is defined by H(K) = {F c K: F is compact, F ≠ 0}. H(K) is itself a metric space under the Hausdorff metric dH. Hyperspaces have been extensively studied by topologists since the 1970's, but the...
This study compared brief, single sessions of physical activity (PA, self-paced treadmill walking) and relaxation/meditation (R/M, the "Body Scan") on positive and negative affect and anxiety measures in female undergraduates. Both were...
Background - Cranial cruciate ligament (CrCL) rupture in the canine stifle is a leading
cause of orthopedic lameness in the dog. Several corrective surgical procedures have
been developed to return dogs to pre-injury function following CrCL...
This paper investigates the development and applications of the Black-Scholes
formula. This well-known formula is a continuous time model used primarily to price
European style options. However in recent decades, observations in financial market...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
Gene therapy; Spinal cord--Wounds and injuries; Tissue engineering
The combination of viral mediated gene delivery, tissue engineering, and Schwann cell (SC) transplantation offer a promising strategy to enhance axonal regeneration and functional recovery following spinal cord injury (SCI). The rationale and...
Sensory neurons; Spinal cord--Wounds and injuries--Research; Pain--Research
This study examined the effects of tissue damage and inflammation on the expression in sensory neurons of P2X3, a gene that has a role in nociception and sensing bladder distension, which is regulated by nerve injury. Tissue damage induces...
Activity-based rehabilitation is important for clinically treating spinal cord injury (SCI). Advances in SCI research are dependent on quality animal models, which rely on our ability to detect functional differences in animals following injury....
Although not a criteria for diagnosis of autism, feeding difficulties are commonly found in this population. The purpose of this thesis is to provide further insight in the area of autism and feeding. Parents of children with and without autism...
Eating disorders in children; Behavior modification
Feeding disorders occur when a child rejects significant amounts of food or drink. Food refusals are maintained by factors which may be behavioral based, due to structural impairments, or a combination of the two. One of the first steps to...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
Evidence suggests that cortical minicolumns are reduced in size and increased in number in individuals with autism spectrum disorder (ASD), especially in the dorsolateral prefrontal cortex (DLPFC). More specifically minicolumns in individuals with...
We formulate an integro-difference model to predict the growth and spatial
spread of a perennial plant population with an age-structured seed bank. We allow
the seeds in the bank to be of any age, producing an infinite system of equations.
The...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
