Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Sartre, Jean-Paul, 1905-1980--Criticism and interpretation; Percy, Walker, 1916-1990--Criticism and interpretation; Hopper, Edward, 1882-1967--Criticism and interpretation; Nichols, Mike--Criticism and interpretation; Existentialism in art;...
Jean-Paul Sartre's existential philosophy concerns the free human individual,
particularly his possibilities to continuously create his own identities. Human existence is
never defined by objects, and he is only determined by his own actions. As...
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
Schiller, Friedrich, 1759-1805. Über die ästhetische Erziehung des Menschen in einer Reihe von Briefen; Schiller, Friedrich, 1759-1805--Philosophy; Play (Philosophy)
Friedrich Schiller's psychological theory of play, his hypothesis about human nature, is embedded in the Aesthetic Letters . Its trans-historical value owes much to the committed interest in life in the late Enlightenment, and the theory itself is...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Hepatitis C virus--Research; Interferon--Therapeutic use; Adenosylmethionine
Hepatitis C virus (HCV) infection is a major cause of chronic liver disease in the United States and is a huge burden on the US healthcare system. The FDA-approved traditional standard of care for HCV is pegylated interferon-alpha (lFNα) combined...
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
G-quadruplexes are thought to have biological importance, with studies based on small molecule interactions and quadruplex-interactive antibodies demonstrating their potential for formation in vivo. One potential biological function of quadruplex...
Nonprofit organizations--Employees; Human services personnel
The goal of this study was to investigate the relationships among demographics variables (age, sex, and ethnicity), organizational culture, interpersonal self-efficacy, and perceived job performance of nonprofit human service workers. The 13...
Spirituality in literature; Religion in literature; Berry, Wendell, 1934---Criticism and interpretation; McCarthy, Cormac, 1933---Criticism and interpretation
This dissertation provides a reading of characters in the novels and short stories of two important contemporary American writers through the lens of spiritual theology. While spirituality has often been understood as necessitating a flight from...
Pituitary tumor transforming gene ( PTTG ), also known as securing, is a novel oncogene that is expressed at high levels in most of the tumors analyzed to date. Overexpression of PTTG in mouse fibroblast(NIH 3T3) cells increases cell proliferation,...
Research--Moral and ethical aspects; Sociology--Research--Moral and ethical aspects
This dissertation is a comparative theoretical analysis of human rights, research ethics and human subjects protection. The history of human rights is a long one, but for the sake of immediacy and focus, the author will limit the discussion to...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
This dissertation examines the relationship between two communication-related dimensions of organizational culture, workplace incivility, and turnover. In particular, it investigates the impact that four human resources practices have on the...
Inflammation is now recognized as an important factor in several age-related diseases such as arthritis, atherosclerosis, multiple sclerosis and diabetes. In each case, sub-clinical chronic inflammation occurs over years and leads to progressive...
Parasites; Medical parasitology; Parasitic diseases
This thesis investigated infection dynamics of parasitic nematodes at both the population
and individual levels by exploring evolutionary and historical aspects of infection as well
as how host-parasite interactions influence virulence. In...
Emotions (Philosophy); Literature--Philosophy; Ethics; Philosophy of mind
This dissertation offers a brief survey of the rise of reason and the tum to the self at the expense of emotion in Western thought. This marginalization of emotion has had deleterious effects on two areas: the cultivation of virtue and the...
This thesis is about graphic representations of violence and subjectivity. Simply stated, the violence in many recent horror films is motivated by a nihilism resulting from frustration with the inadequacy of contemporary subjectivity. I want to...
Tick-borne diseases; Health behavior; Health attitudes; Health education--Social aspects
Human monocytic ehrlichiosis (HME), a tick-borne disease that has recently surfaced in
the United States, exists in regions where the tick vector population is established. This
study utilizes methods that look beyond identifying high-risk regions,...
