Chapter 1 detailed the synthesis method of hydroxamate peptides derivatives of pentapeptide Ac-PHSXX\'-N-NH2 by solid phase hydroxamate peptide synthesis method. The glutamic acid/aspartic acid side chain was modified to hydroxamic acid by on resin...
The properties of gold nanoparticles (GNP) holds promising potential for drug delivery, diagnostics, plasmonic photothermal therapy of diseases, electronics, catalysis, and photovoltaics (Liu et al., 2006; Huang et al., 2003; Thompson, 2007;...
A process for fabricating PMOS transistors and test devices has been developed for educational purposes as part of a microfabrication undergraduate/graduate laboratory course at the University of Louisville. This is to help students from multiple...
In blood coagulation, the serine protease thrombin is a multifaceted enzyme that interacts with multiple proteins. Thrombin utilizes two anion binding exosites (ABE-I and II) to supplement binding to fibrinogen and to the platelet receptor GpIbα,...
Energy independence requires that the nation reduce its dependence on foreign oil imports. This can be achieved through electrification of transportation vehicles if proper battery technology can be developed. In addition, the renewable energy...
This dissertation describes galvanic exchange of silver (Ag) nanostructures with PdCl42- in 1) various PdCl42- concentrations, 2) the presence of 0.1 M cetyitrimethylammonium bromide (CTAB), and 3) the presence of 0.1 M potassium bromide (KBr). It...
Soon after the atomic theory was established, it was found that the plant uses as sources of food not only the air and water, but also different constituents of the soil, dissolved in the soil moisture—the mineral nutrients. Ashes of different...
Na,K-ATPase is essential for the regulation of cytoplasmic Na+ and K+ levels in lens cells. Insufficient Na,K-ATPase activity is associated with cataract formation. Based on earlier studies in which Src-tyrosine kinase inhibitors were found to...
This dissertation describes (1) size-dependent electrochemical oxidation/stripping of gold and silver nanoparticles (NPs), (2) alloying of copper with gold nanoparticles at underpotential deposition potentials, (3) electrochemical characterization...
Electroactive polymers (EAPs), including conducting polymers (CPs) such as polyaniline (PAn), and hydrogels are exciting areas of research in disciplines such as biomedical engineering, with the goal of creating low-cost, lightweight, non-toxic...
This dissertation deals with various imidazole compounds with emphasis on hydrogen bond interactions and weaker intermolecular forces. New amide functionalized polyimidazole metal binding pockets are able to form intramolecular six-membered...
Hyaluronan (HA) is a major structural component of the ocular vitreous humor
(VH) and lipids are essential building blocks of cell membranes. However, little is known
about their possible interactions. The VH is known to undergo liquefaction...
Enzymatic hydrolysis is the most common method of producing fermentable sugars from lignocellulosic biomass. Limitations to this step include the high cost of enzymes, and the time required to process the biomass. To increase the throughput and...
Rapid Electrokinetic Patterning (REP) is a relatively new method for collecting and manipulating micrometer-scale particles at an electrode surface. REP is an AC electrokinetic technique that uses induced fluid motion to capture and manipulate...
Electronic surveillance; Computer networks--Design and construction; Computer crimes
Peer-to-peer networks have been growing in popularity over the past decade. There have been many new innovations that greatly improve access to a wide variety of content. This expanded capability combined with a strong sense of anonymity has given...
Copper--Physiological effect; Copper in the body; Heart--Hypertrophy
Previous studies have shown that copper (Cu) supplementation at physiologically relevant levels reverses cardiac myocyte hypertrophy induced by phenylephrine (PE), and that this effect was VEGF-dependent. Yet, the amount of VEGF in the media was...
Most of the structures in submillimeter-scale engineering are created from thin films, making them essentially two-dimensional (2D). Significant work has been done to fabricate 3D structures using self-folding, a deterministic form of...
It shall be the object of this investigation to measure the hydrogen ion concentration in lead acetate solutions and to apply the measurements to the control of color in the preparation of chrome yellow pigments. Lead acetate solutions of high...
Few previous studies have compared microbial communities in subterranean and surface environments. Chemical analyses used to characterize the surface and cave microbial environments indicated limited exchange between surface and subsurface waters....
Assessing the functionality of the endothelium can provide insight into the initiation and formation of arterial diseases. One of the most important functions of the endothelial layer is its permeability. The integrity of the cell monolayer and its...
