Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
Due to of the rise in numbers of persons experiencing homelessness, communities are working to restrict access that homeless individuals have to public spaces. Many cities across the nation have criminalized aspects of homelessness in attempts to...
Law and legislation--Kentucky; Constitutions--Kentucky
Kentucky's third constitution, ratified by voters in 1850 is important historically as the first state charter for which complete record of the convention that drafted it was published, making it possible to research the intentions of the framers. ...
Premenopausal women have fewer and less severe strokes when compared to postmenopausal females and aged matched males. The most obvious factor that could account for the observed difference is the physiological activity of Estrogen. Numerous...
Nerves--Regeneration; Spinal cord--Wounds and injuries--Treatment
These studies set out to identify strategies to rescue and repair the adult nervous system. First, we investigated the role of ciliary neurotrophic factor (CNTF) in 5HT1A receptor-induced neurogenesis in the rodent brain. Systemic treatment with an...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
20S proteasome, essential component of protein degradation mechanism, is important to maintain homeostasis. Its malfunctions have been associated with several pathological conditions. This study presents an extensive study of murine cardiac 20S...
The conversion of Scandinavia, Iceland and Finland occurred over many years and resulted in the formation of Scandinavian monarchies, a strong Icelandic parliament, and an loosely organized Finnish nation. The conversion of Northern Europe was...
Hypoxia is characterized by an inadequate oxygen supply to the tissues in
proportion to their metabolic needs, and is a primary factor in traumatic CNS
injury, strokes, cardiopulmonary diseases, and obstructive sleep apnea. The
cAMP-dependent...
Sensory neurons; Spinal cord--Wounds and injuries--Research; Pain--Research
This study examined the effects of tissue damage and inflammation on the expression in sensory neurons of P2X3, a gene that has a role in nociception and sensing bladder distension, which is regulated by nerve injury. Tissue damage induces...
Theaters--Kentucky--Louisville; Louisville (Ky.)--Buildings, structures, etc.
A child is considered by some psychologists to pass through on its way to manhood the stages through which the race has passed on its way to civilization. If this is true of a single man, might it not equally be true of a community of men? Have not...
How do words represent emotional states, and how closely are they clustered to an actual emotion? Opinions vary as to how many emotions there are, and whether (or which) emotions are basic. Generally, many agree that basic emotions include fear,...
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Page seven of this issue is very faded.
African Americans; African American educators; Segregation in higher education; Civil rights workers; African Americans--Education (Higher); Race relations; University of Louisville; University of Kentucky; Louisville Municipal College for Negroes...
Oral history interview conducted with Lyman T. Johnson on May 6, 1976 by Dwayne Cox. Mr. Johnson, a civil rights activist and educator focuses on Johnson’s involvement in the effort to integrate the University of Louisville and the University of...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
United States. Army--History--Civil War, 1861-1865; Confederate States of America. Army; Soldiers--Kentucky--Psychology--History--19th century; Soldiers--Kentucky--Attitudes--History--19th century
Beginning with Bell Irvin Wiley's 1943 The Life of Johnny Reb: The Common Soldier of the Confederacy, historians have produced many works describing the motivations for soldiers to enlist and serve during the Civil War. However, because they often...
