Na,K-ATPase is essential for the regulation of cytoplasmic Na+ and K+ levels in lens cells. Insufficient Na,K-ATPase activity is associated with cataract formation. Based on earlier studies in which Src-tyrosine kinase inhibitors were found to...
N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ASP). NAT1 catalyzes N-acetylation of arylamines as well as the 0-acetylation...
This thesis begins by reviewing human N-acetyltransferases (Chapter I), then outlines experiments involving human hepatocytes and rat N-acetyltransferases (Chapters II-V). These experiments facilitated the development of a dissertation project...
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
Teacher-student relationships; Interaction analysis in education; Problem youth--Education (Secondary)
The interactions between teachers and students provide a venue for instructional delivery and ultimately student achievement in the school setting. However, not all students experience positive interactions with teachers in the typical classroom...
Human arylamine N-acetyltransferase (NAT) is a phase II cytosolic enzyme that occurs as two isozymes, NAT1 and NAT2. This family of polymorphic enzymes catalyzes the detoxification and/or activation of many aromatic and heterocyclic amine drugs and...
Anxiety in children; Resilience (Personality trait) in children; Temperament in children; Child development
Anxiety is a common and debilitating disorder in children. Until recently, research in the field of child anxiety has focused on the identification of specific risk factors in the development of child anxiety. More recent studies have begun to...
The purpose of this project was to compare the accuracy and reliability of linear measurements made on 2D projections and 3D reconstructions using Dolphin 3D software (Chatsworth, CA) as compared to direct measurements made on human skulls. The...
Mixed-effects model is an efficient tool for analyzing longitudinal data. The random effects in mixed-effects model can be used to capture the correlations among repeated measurements within a subject. The time points are not fixed and all...
Hyaluronan (HA) is a major structural component of the ocular vitreous humor
(VH) and lipids are essential building blocks of cell membranes. However, little is known
about their possible interactions. The VH is known to undergo liquefaction...
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or...
Longitudinal studies occupy an important role in scientific researches and clinical trials. When taking the analysis of longitudinal data, investigators are often confronted with missing data which will produce potential biases, even in...
DNA microarrays--Statistical methods; Gene expression--Statistical methods
Data derived from gene expression microarrays are frequently used to identify candidate genes which can characterize and distinguish between two biological phenotypes. A key step in this process is the selection of an appropriate test statistic to...
Optical properties of carbon nanotubes have recently attracted considerable amount of attention. Due to there direct band gap material characteristic these and dimension of the order of nano meters they find potential applications in the field of...
Within the Appalachian hills of eastern Kentucky, large-scale coal mining operations are directly altering the headwater landscape through the construction of hollow fills. These man-made landforms and their associated in-stream structures alter a...
In recent years, a number of computational and statistical problems for identifying SNP-SNP interactions in high dimensional survival data have been studied, and several data mining approaches have been proposed. However, the relative performance...
While democracy was developing, while men were seeking to reform national politics and to find some means by which the people might be represented justly in the government, a new movement entered into literature to give it a broadened scope and a...
Determining the etiology of skeletal malocclusion is an important diagnostic step in treatment planning patients with maxillofacial anomalies. Aims: To describe cranial base morphology using cone beam computed tomography (CBCT) images and correlate...
Objective . To compare the in vitro reliability and accuracy of linear measurements between cephalometric landmarks on CBCT 3D images with varying basis projection images to direct measurements on human skulls. Methods . Sixteen linear dimensions...
Coronary heart disease--Treatment--Cost effectiveness; Angioplasty; Medical laws and legislation--Kentucky
A myocardial infarction (MI) occurs when blood supply to the heart is cut off by a blockage in one of the coronary arteries. Most hospitals treat a patient with thrombolysis or a percutaneous coronary intervention (PC I). The latter has been...
