Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial...
Marginal inference for waiting times in multi-stage time-to-event models is complicated by right censoring of observations as well as the prior history of events in the model. In general, complications arise due to the evolution of the censoring...
Nonparametric statistics; Estimation theory; Distribution (Probability theory)
Multistate models are a type of multi-variate survival data which provide a framework for describing a complex system where individuals transition through a series of distinct states. This research focuses on nonparametric inference for general...
Medical records--Data processing; Data mining; Medical care--Data processing; Coronary heart disease--Treatment
The goal of this study is to use a data mining framework to assess the three main treatments for acute myocardial infarction: thrombolytic therapy, percutaneous coronary intervention (percutaneous angioplasty), and coronary artery bypass surgery....
This paper investigates the development and applications of the Black-Scholes
formula. This well-known formula is a continuous time model used primarily to price
European style options. However in recent decades, observations in financial market...
Radio frequency allocation; Wireless communication systems
Recently, the need for wireless and mobile communications has grown tremendously and it is expected that the number of users to be supported will increase with high rates in the next few years. Not only the number of users, but also the required...
The complexity of high-dimensional data creates a number of concerns when trying to analyze it. This data often consists of a response or survival time and potentially thousands of predictors. These predictors can be highly correlated, and the...
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
We formulate an integro-difference model to predict the growth and spatial
spread of a perennial plant population with an age-structured seed bank. We allow
the seeds in the bank to be of any age, producing an infinite system of equations.
The...
MicroRNAs (miRNAs) regulate gene expression at the post-transcriptional level by repressing translation or stimulating mRNA degradation. In this study, I tested the hypothesis that miRNAs are differentially expressed in antiestrogen-sensitive MCF-7...
Arrhythmia; Heart--Diseases; Heart beat; Heart conduction system
Introduction: Hyperhomocysteinemia (HHcy) is a pathological condition characterized by excessive levels of plasma homocysteine (Hcy). Patients with HHcy are reported to be at risk for arrhythmias like atrial fibrillation and sudden cardiac death...
Online organizations are always in search for innovative marketing strategies to better satisfy their current website users and lure new ones. Thus, recently, many organizations have started to retain all transactions taking place on their website,...
The broad long-term objectives of this research project are to increase the percentage of women who seek care for urinary incontinence. The specific aims of this research project are: (1) Use Lauver's Theory of Care Seeking Behavior to identify...
Outerplanar graphs are planar graphs that have a plane embedding in which each vertex lies on the boundary of the exterior region. An outerplanar graph is maximal outerplanar if the graph obtained by adding an edge is not outerplanar. Maximal...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue is four pages and there is a tear from the side of pages one and two.
Three-dimensional imaging in medicine; Diagnostic imaging; Dental care
CBCT in endodontics demonstrates anatomic features in 3D that intraoral, panoramic, and cephalometric images cannot. CBCT units reconstruct the projection data to provide interrelational images in three orthogonal planes (axial, sagittal, and...
Given a metric space (K, d), the hyperspace of K is defined by H(K) = {F c K: F is compact, F ≠ 0}. H(K) is itself a metric space under the Hausdorff metric dH. Hyperspaces have been extensively studied by topologists since the 1970's, but the...
