Social anxiety is prevalent and debilitating. Contemporary models of social
anxiety posit that negative, self-focused thought aids in the maintenance of social anxiety
symptoms. Although these models emphasize in-situation cognition, recent...
The Technical Advisory Group (TAG) of the Innovative Treatment Remediation Demonstration Program (ITRD) made technology recommendations after reviewing thirty in situ remediation technologies for implementation at the Paducah Gaseous Diffusion...
Contamination can be very difficult to remove from water. Once this water seeps into the ground, the difficulty grows exponentially. The Paducah Gaseous Diffusion Plant, located in Paducah, Kentucky, has contaminated the groundwater. The...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
Monoclonal antibodies directed toward tumor associated antigens are FDA approved anticancer reagents used commonly in the clinic. Administered antibodies initiate tumor cell death through several mechanisms. Improving immune mediated mechanisms,...
The leading cause of death in the United States is cardiovascular disease, a result of atherosclerosis. The reducing agent N-(2-Mercaptopropionyl)glycine (MPG) as been found to be an effective antioxidant therapy in a number of conditions, and our...
Spinal cord injury (SCI) can be divided into two distinct stages, an initial mechanical impact and a later "secondary injury" resulting from a cascade of cytokines triggering a spreading demyelination and apoptosis of neurons and glia...
This quantitative dissertation examines risk assessment and recidivism of child maltreatment to determine the relationship between child protective services provided by the Kentucky Department of Protection and Permanency and risk of harm. A chart...
The aim of the study was to determine the incidence and imaging characteristics of soft tissue calcifications on cone beam computed tomography (CBCT). 556 CBCT image datasets were reviewed and 308 included. The following conditions were recorded:...
Protein C (PC) is an important anticoagulant, antithrombotic, and antiinflammatory in blood plasma. PC deficiency can lead to severe venous thrombotic events, including lung embolism, stroke, and heart attack. In the body, PC is activated only when...
Embryonic development requires the orchestration of temporally precise genetic events that culminate in the formation of a complete organism. The molecular mechanisms responsible for ontogenesis are regulated by environmental and somatic factors in...
Responding to research gaps in both cycling and women's rights history, the purpose of my thesis is to investigate conceptualizations of cycling in the 1890's suffrage press. I analyze six aspects of cycling in suffrage periodicals: advice and tips...
Dehydroepiandrosterone (DHEA) is a C-19 adrenal steroid and the most abundant circulating hormone in humans. Since circulating levels decline in late adulthood, treatment of humans with DHEA has been suggested to have beneficial health effects....
Rising environmental concerns due to our rising population ad energy demand along with our excessive dependence on fossil fuels has created an urgent need to find clean, renewable and carbon free source of energy. Photoelectrochemical (PEC) water...
Pancreatic adenocarcinoma is the fourth leading cause of cancer death in the United States. It is identified by its rapid, invasive progression with a profound resistance to treatments such as chemotherapy. Unfortunately, there is a lack of...
Women--Kentucky--Louisville; Social reformers--Kentucky--Louisville--History; Morel, Louise C., b. 1871
Louise C. Morel was a leading social reformer in Louisville from 1917 through the early 1940s. Morel's work is a primary example of the continuation of Progressive Era ideals into the decades after the traditional end of the Progressive Era....
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
Monophosphoryl Lipid A (MPLA), a derivative of LPS endotoxin, is a TLR4 agonist that displays as little as 0.1-1% as much toxicity as its parent molecule while retaining immunostimulatory properties. We discovered that MPLA activates a TRIF-biased...
c-Myc dysregulation is one of the most common abnormalities found in human cancer. MicroRNAs (miRNAs) are functionally intertwined with the c-Myc network as multiple miRNAs are regulated by c-Myc, while others directly suppress c-Myc expression. In...
This thesis is an exploration of Black cultural space and its influence on the
retention, adaptation, and transmission of African folktales during and after the
antebellum era. During slavery, the survival of kinship and family helped to create
an...
