It has been shown that GSK3 β plays a critical role in the inflammation response by differentially regulating MyD88-dependent pro- and anti-inflammatory cytokines production in TLR4-stimulated innate immune cells. The work included in this...
Background The anthracycline doxorubicin (DOX) is widely used as an effective antineoplastic drug. Cardiotoxicity leading to congestive heart failure is the primary factor limiting the clinical use of DOX. However, although a variety of approaches...
Griffithsin (GRFT) is a carbohydrate binding protein derived from the red alga Griffithisia sp. that has been shown to effectively interfere with the cellular attachment and infectivity of a number of viruses, including HIV-1. However, it is...
The secondary visual pathway, from the retina through the superior colliculus and pulvinar nucleus has been linked to spatial attention (Snow et aI., 2009; Arend et aI., 2008) movement planning and motor response to visual stimuli (Wilke et aI....
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 18. No. 9. but is actually Vol. 18. No. 11. There are portions missing along the edges of each page...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 31. No. 47. but is actually Vol. 31. No. 38.
Heart--Hypertrophy; Hydrogen sulfide--Therapeutic use
Background: Although matrix metalloproteinase (MMPs) and tissue inhibitor of metalloproteinase (TIMPs) play a vital role in tumor angiogenesis and TIMP-3 causes apoptosis, their role in cardiac angiogenesis is unknown. Interestingly, a disruption...
Liver--Diseases--Genetic aspects; Liver--Effect of arsenic on; Arsenic--Toxicology
Arsenic exposure in drinking-water is a significant worldwide health problem. It causes adverse human health effects, such as cancer, increases the risks for others such as cardiovascular disease, and accelerates atherosclerosis. In this study, we...
Through differential display PCR, Munc13-3 was identified as a gene whose relative expression in the visual cortex corresponds to critical period plasticity. Expression of the gene was low at the peak of the critical period and expression was high...
Mycobacterium tuberculosis causes the often-fatal infectious disease Tuberculosis, and infects approximately one third of the world's population. Gaining a better understanding of how these bacteria regulate gene expression for intracellular...
Dielectrophoresis (DEP) is an electrokinetic force capable of attracting or repelling neutrally charged particles due to a non-uniform electric field [1, 2]. Positive dielectrophoresis attracts particles in the region of the highest electric field...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Periodontal disease arises from excessive host inflammatory responses to the tooth-associated microbial biofilm, known as dental plaque. Severity ranges from superficial inflammation of the gingivae (gingivitis) to extensive destruction of...
Periodontitis is a chronic, destructive inflammatory disease of the supporting
tissues of the teeth with a high prevalence among adults. While the complete
pathogenesis of periodontitis remains unclear, it is initiated and sustained by...
The properties of gold nanoparticles (GNP) holds promising potential for drug delivery, diagnostics, plasmonic photothermal therapy of diseases, electronics, catalysis, and photovoltaics (Liu et al., 2006; Huang et al., 2003; Thompson, 2007;...
Spinal cord--Wounds and injuries; Stretch (Physiology)
An increasing amount of healthcare resources is used for the treatment and prevention of contractures in patients with spinal cord injury (SCI), with stretch and passive movements remaining the most prominent intervention methods. The results of...
Single Walled Carbon Nanotubes (SWNTs), Double Walled Carbon nanotubes (DWNTs) and C60@SWNT (peapods) are three of well-ordered all-carbon nanostructures. Peapods are SWNTs filled with C60 fullerene peas. At high temperatues, C60 molecules coalesce...
Age-related macular degeneration (ARMD) and retinitis pigmentosa (RP) are the two leading causes of blindness in the world today. Despite enormous efforts and advances in clinical treatment of eye diseases, there is no established method or cure of...
The purpose of this dissertation was to demonstrate that a new method of direct intracellular energy delivery was effective in maintaining viability of in vitro Human Umbilical Vein Endothelial Cells (HUVECs) when exposed to chemical ischemia for...
Medical education; Medical students; Hospital College of Medicine, Louisville (Ky.)
Catalog for Hospital College of Medicine 1881-1882. Includes board of trustees and medical faculty, program information, enrolled students, and graduates 1874-1881. Printed on cover: Eighth Annual Announcement of the Hospital College of Medicine,...
Medical education; Medical students; Hospital College of Medicine, Louisville (Ky.)
Catalog for Hospital College of Medicine 1879-1880. Includes board of trustees and medical faculty, program information, enrolled students, and graduates 1874-1879. Printed on cover: Sixth Annual Announcement of the Hospital College of Medicine,...
