Introduction: Autism is a complex developmental disability that typically appears during
the first three years of life, and is the result of a neurological disorder that affects the
normal functioning of the brain, impacting development in the...
Recent studies indicate post-translational deacetylation by members of the superfamily of histone deacetylase complexes (HDACs) is necessary for oligodendrocyte precursor cell (OPC) differentiation into mature oligodendrocytes (OLs). However, it...
Human adult olfactory epithelium contains neural progenitors (hONPs) which replace damaged cellular components throughout life. Methods to isolate and expand the hONPs have been developed in our laboratory. In response to morphogens, the hONPs...
Corpus callosum; Diagnostic imaging; Autism--Diagnosis
Early detection of human disease in today’s society can have an enormous impact
on the severity of the disease that is manifested. Disease such as Autism and Dyslexia,
which have no current cure or proven mechanism as to how they develop, can...
Premenopausal women have fewer and less severe strokes when compared to postmenopausal females and aged matched males. The most obvious factor that could account for the observed difference is the physiological activity of Estrogen. Numerous...
Parkinson's disease--Treatment; Stem cells--Therapeutic use
Parkinson's disease (PD) is a hypokinetic movement disorder resulting from the
progressive neurodegeneration of the dopaminergic nigrostriatal system in the brain and
the resulting imbalance between dopamine and acetylcholine in the basal ganglia...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
The pulvinar is the largest nucleus of the human dorsal thalamus and is affected in a variety of brain disorders, such as schizophrenia. The experiments described in this dissertation elucidate key features of tecto-pulvino-cortical pathways as a...
The goals of this dissertation is to further the understanding of the roles of two genes identified by differential display polymerase chain reaction (ddPCR) of cat visual cortex as candidate genes to play a role in visual cortical plasticity....
Autism Spectrum Disorder (ASD) is an idiopathic pervasive neurodevelopmental disorder associated with various neuropathologies and immunological dysfunctions. Cytokines are regulatory proteins that facilitate communication between the immune and...
Spirituality; Spirituality in art; Nietzsche, Friedrich Wilhelm, 1844-1900
This thesis explores the history of human spirituality and its present ambiguous place in our modern secular world. Accompanying the written thesis is documentation of my creative work by the same title. First I will describe spirituality as a...
Cortical and tectal inputs to the caudal LPN in the rat were examined using anatomical and physiological techniques. Pyramidal cells in layer 6 of the visual cortex and wide-field vertical cells in the stratum opticum of the superior colliculus...
In the United States substance abuse takes a toll that is costly in both economic and human terms. In 2005 we paid 467.7 billion dollars to address the consequences of substance abuse, and each year we have lost an estimated 537,000 of our fellows...
The secondary visual pathway, from the retina through the superior colliculus and pulvinar nucleus has been linked to spatial attention (Snow et aI., 2009; Arend et aI., 2008) movement planning and motor response to visual stimuli (Wilke et aI....
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. No. 41. but is actually Vol. 32. No. 45.
Integration; African Americans; Hospitals; Red Cross Hospital (Louisville, Ky.)
D.W. Beard was interviewed on November 29, 1979 about the Red Cross (Community) Hospital. He was a member of the board of Community Hospital, which was known previously as Red Cross Hospital. He discusses public perception of the hospital and the...
Periodontitis--Age factors; Natural immunity; Age factors in disease
Periodontal disease arises from excessive host inflammatory responses to the tooth-associated microbial biofilm, known as dental plaque. Severity ranges from superficial inflammation of the gingivae (gingivitis) to extensive destruction of...
Older people--Mental health; Philosophy of mind; Cognitive science--Health aspects
Declines in social resources and in the quality of interpersonal interactions have been observed in some older adults. Unawareness of ability is a clinical problem that has been found in some older adults with dementia, but has also been found in...
Military nursing--History; World War, 1914-1918--Women; World War, 1914-1918--Medical care; Women and war--History--20th century
World War I resulted in the deaths of over 8,500,000
military personnel and in addition, millions of civilians.
There were not enough doctors to provide the necessary
medical care for the masses of seriously sick and wounded,
and other than in...
Youth--Employment; Teenagers--Health and hygiene; Industrial safety; Safety education, Industrial
Teenaged workers are twice as likely to be injured on the job as adult workers, and face a
number of differences developmentally and psychosocially that present challenges for
their safety at work. Little research has focused on the tasks that...
