Background. Progression of alcoholic liver disease (ALD) is associated with an increase in fibrin extracellular matrix (ECM) and inflammation. Previous studies have shown that this accumulation of fibrin in ALD is mediated by impaired fibrinolysis....
In order to satisfy customer expectations, a ground vehicle must be designed to meet a broad range of performance requirements. A satisfactory vehicle design process implements a set of requirements reflecting necessary, but perhaps not sufficient...
Simplified modeling generates a great deal of interest in the area of crashworthiness analysis. Modeling methods used to create simplified computer models for crashworthiness have been well developed. In advanced simplified models, researchers...
Arsenic--Physiological effect; Cardiovascular system--Diseases; Liver--Effect of arsenic on; Arsenic--Toxicology
Chronic arsenic exposure is associated with increased cardiovascular disease (CVD). Prenatal arsenic exposure at 49 ppm arsenic accelerates atherosclerosis underlying CVD in ApoE-/- mice, but the mechanism is unknown. This dissertation examines the...
High-throughput sequencing has provided a myriad of genetic data for thousands of organisms. Computational analysis of one data type, expressed sequence tags (ESTs) yields insight into gene expression, alternative splicing, tissue specificity gene...
Universities and colleges--Alumni and alumnae--United States--Societies, etc.; Universities and colleges--Alumni and alumnae--Charitable contributions--United States
Public higher education institutions are presently faced with a perfect storm of financial crises. State appropriations are on the decline, endowments have been substantially reduced as a result of the declining stock market, generally poor...
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
The aim of the study was to determine the incidence and imaging characteristics of soft tissue calcifications on cone beam computed tomography (CBCT). 556 CBCT image datasets were reviewed and 308 included. The following conditions were recorded:...
Item response theory; Goodness-of-fit tests; Monte Carlo method
Item response theory (IRT) is expanding to diverse research settings, without accompanying access to easily implemented model fit methods. One simple model fit approach involves x2/df ratios. However, its utility is not known across several...
The design of this thesis is to re-engineer the Enigma cipher to make it a viable, secure cipher for use on current computers. The goal is to create a cipher based on an antiquated mechanical cryptography device, the Enigma Machine, in software and...
Buildings; University of Louisville--Buildings; Research facilities; Streets;
Vogt Building seen from across Eastern Parkway. Location: Belknap Campus: Eastern Parkway adjacent to Sackett Hall. Current uses: Computer-aided engineering. Named in honor of Henry Vogt, Louisville industrialist. The Henry Heuser, Sr. family -...
In today's world of private information and mass communication, there is an ever increasing need for new methods of maintaining and protecting privacy and integrity of information. This thesis attempts to combine the chaotic world of cellular...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. Pages one and seven of this issue are very faded.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 21. No. 21. but is actually Vol. 21. No. 22. There is a tear down the center of each page of this...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There is a tear down the center of each page of this issue.
Among gynecological malignancies, carcinoma of the cervix is the leading cancer type worldwide. Conversely, vaginal tumors account for an incidence of approximately 1-2% of lower genital tract malignancies. Interestingly, the major shared risk...
Wheel Slide Protection Systems (WSP Systems) or Anti-Skid Devices for rail vehicles have to go through a series of Dynamometer tests before test runs with equipped rail vehicles are permitted. The simulation tests are performed on Wheel Slide...
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with free radicals, however, SFN works by inducing Nrf2, a transcription factor that binds to...
In submitting this thesis, the writer does not pretend to have made even an approximation of exhaustive study of the Hecyra: this thesis is merely a study of the play from certain viewpoints which also make no claim to completeness. No originality...
