Standard regularity assumptions for regression models are not satisfied in segmented regression models with an unknown change point, and consequently standard asymptotic results and inferential methods for confidence estimation are not applicable....
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 32. No. 7. but is actually Vol. 33. No. 10. Page one of this issue is duplicated in the microfilm...
Heart failure is the most frequent cause of mortality in western countries. Currently, there is no cure treatment for heart failure and the long term survival rate following heart failure is poor, with one third of patients dying within a year of...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 18. No. 29. but is actually Vol. 18. No. 30.
Alcoholic liver disease (ALD) is a serious concern for the world's population. It is one of the leading causes of death and is also a huge economic burden. The biochemical mechanisms responsible for ALD are incompletely understood, therefore there...
The role of the active site tyrosine residue in the Co-C5' bond activation in the
context of adenosylcobalamin-dependent mutases has been computationally
investigated. The density functional, complete active space self-consistent field
and quantum...
Sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables, is known to confer antioxidant protection in vivo. Rather than directly reacting with free radicals, however, SFN works by inducing Nrf2, a transcription factor that binds to...
This dissertation describes research focused on the synthesis, polymerization and
applications of cationic aminooxy lipids. An efficient and convenient method was
developed to stabilize liposomes using 'click chemistry'. The 'click...
Integrins are major receptors for cell adhesion to the extracellular matrix, and play key roles in various cellular processes including adhesion, migration, proliferation and survival. Apart from developmental and physiological events, integrins...
Ribosomal biogenesis failure may contribute to neurodegenerative diseases, while its excessive activation has been shown to drive tumor growth. As ribosomal production is initiated and regulated by the Pol1-mediated transcription of rRNA genes in...
As my curatorial thesis project, I chose to curate an exhibit of George Washington Morrison's paintings. George Morrison was a well-known portrait painter in New Albany, Indiana during his time here from 1840-1893. His paintings are on display in...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. There is a tear down the center of each page of this issue and a small portion is missing from the bottom of pages one...
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 14. No. 42. but is actually Vol. 14. No. 44.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 29. No. 27. but is actually Vol. 29. No. 29. This issue is four pages.
The Louisville Leader was an African-American newspaper published from 1917 to 1950 by I. Willis Cole in Louisville, Kentucky. This issue says Vol. 29. No. 36. but is actually Vol. 29. No. 39. This issue is four pages.
A projected high penetration of battery electric vehicles (BEV s) in the market will introduce an additional load in the electricity grid. Furthermore, uncontrolled BEV charging from residential users will exacerbate the existing peak load during...
Kentucky--History--Civil War, 1861-1865; United States--History--Civil War, 1861-1865
In the early days of 1861, Kentucky, torn between her allegiance to the federal government and her sympathy for the South, with her citizenry so divided that hardly a family in the state stood united, vainly endeavored to carve out for herself a...
Heart--Hypertrophy; Heart--Physiology; Sugar in the body; Metabolism; Diabetes--Research
Heart failure is recognized as a major cause of death among diabetics. In type I and II diabetes, glucose uptake, glycolysis and pyruvate oxidation are impaired, and fatty acid utilization increases. These alterations in metabolism contribute...
